FB2024_03 , released June 25, 2024
Allele: Dmel\Lip4UAS.cLa
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General Information
Symbol
Dmel\Lip4UAS.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0302645
Feature type
allele
Associated gene
Dmel\Lip4
Associated Insertion(s)
Carried in Construct
PBac{UAS-Lip4.L}
Also Known As
UAS-Lip4
Key Links
Transgenic product class
cDNA
(Liu et al., 2015)
wild_type
(Liu et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Liu et al., 2015)
wild_type
(Liu et al., 2015)
Mutagen
in vitro construct
(Liu et al., 2015)
Progenitor genotype
Carried in construct
PBac{UAS-Lip4.L}
Cytology
Description

UAS regulatory sequences drive expression of Lip4 coding sequences (corresponding to cDNA clone RE12242).

(Liu et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Lip4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Lip4UAS.cLa/Scer\GAL4ninaE.PT is a non-suppressor of eye photoreceptor cell | somatic clone | adult stage phenotype of fh1

      (Chen et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Lip4Scer\UAS.cLa under the control of Scer\GAL4ninaE.PT fails to rescue the neurodegeneration and electrophysiology defect seen in fh1 mutant photoreceptor clones.

      (Chen et al., 2016)

      Expression of Lip4Scer\UAS.cLa in sicilyE mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

      Expression of Lip4Scer\UAS.cLa in Aats-metFB mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

      Expression of Lip4Scer\UAS.cLa in MarfB mutant clones partially restores the shape, density and number of identifiable rhabdomeres, indicating that reducing lipid droplet accumulation partially alleviates neurodegeneration.

      Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in MarfGD11094-knockdown glia.

      Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in MarfGD11094-knockdown glia.

      Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in Aats-metKK108492-knockdown glia.

      Neuronal expression of Lip4Scer\UAS.cLa (under the control of Scer\GAL4elav.PU) suppresses lipid droplet accumulation in ND-42GD6220-knockdown glia.

      Knockdown of Marf in neurons (MarfninaE.GD11094) and overexpression of Lip4Scer\UAS.cLa in glia (under the control of Scer\GAL454C) lowers lipid droplet accumulation and delays neurodegeneration.

      Knockdown of ND-42 in neurons (ND-42ninaE.GD6220) and overexpression of Lip4Scer\UAS.cLa in glia (under the control of Scer\GAL454C) lowers lipid droplet accumulation and peroxidation and delays neurodegeneration.

      (Liu et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Lip4Scer\UAS.cLa
      Lip4UAS.cLa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)