FlyBase Allele Report: Dmel\Oatp30B[Δ2-14]

General Information

Symbol

Dmel\Oatp30B^Δ2-14

Species

D. melanogaster

Name

FlyBase ID

FBal0299638

Feature type

allele

Associated gene

Dmel\Oatp30B

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Meyer et al., 2014)

Mutagen

FLPase

(Meyer et al., 2014)

Progenitor genotype

PBac{WH}Oatp30B^f00105

(Meyer et al., 2014)

P{XP}Oatp30B^d00199

(Meyer et al., 2014)

Caused by aberration

Df(2L)Oatp30B^Δ2-14

Cytology

Description

Recombination between the progenitor insertions results in deletion of exons 2-14 of Oatp30B, including the predicted start codon, and only leaves a small portion of the open reading frame in the last exon.

(Meyer et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:9,522,964..9,538,276 [+]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Meyer et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | larval stage

(Meyer et al., 2014)

female fertile

(Meyer et al., 2014)

male fertile

(Meyer et al., 2014)

viable

(Meyer et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

The larval nervous system develops normally in Oatp30B^Δ2-14 mutants.

Mutants show abnormal larval migratory behaviour and crawl slower than wild type. Head sweeping behaviour is normal.

(Meyer et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Oatp30B^Δ2-14 is an enhancer of abnormal behavior phenotype of nolo^Δ4-12

(Meyer et al., 2014)

Other

Statement

Reference

Oatp30B^Δ2-14, nolo^Δ4-12 has partially lethal - majority die phenotype

(Meyer et al., 2014)

Oatp30B^Δ2-14, nolo^Δ4-12 has female sterile phenotype

(Meyer et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

In contrast to either single mutant, nolo^Δ4-12 Oatp30B^Δ2-14 double mutants show dramatically reduced rates of eclosion and female sterility. The ventral nerve cord is shaped normally in double mutants. Head sweeping behaviour in double mutant larvae is dramatically reduced compared to either single mutant.

(Meyer et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Oatp30B^Δ2-14

Oatp30BΔ^2-14

(Meyer et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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