FlyBase Allele Report: Dmel\Zip99C[UAS.cXa]

General Information

Symbol

Dmel\Zip99C^UAS.cXa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Xiao

FlyBase ID

FBal0298303

Feature type

allele

Associated gene

Dmel\Zip99C

Associated Insertion(s)

Carried in Construct

P{UAS-Zip99C.X}

Key Links

Transgenic product class

cDNA

(Xiao et al., 2014)

wild_type

(Xiao et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Xiao et al., 2014)

wild_type

(Xiao et al., 2014)

Mutagen

in vitro construct

(Xiao et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-Zip99C.X}

Cytology

Description

UASt regulates expression of Zip99C cDNA.

(Xiao et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Zip99C

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Xue et al., 2022)

modeled by Pink1^RNAi.UAS.cYa

(Xue et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Scer\GAL4^NP3084-mediated expression of Zip99C^Scer\UAS.cXa results in whole body iron levels increasing, while zinc levels stay unaltered.

(Xiao et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa has visible | adult stage phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

NOT Enhancer of

Statement

Reference

Zip99C^UAS.cXa/mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-enhancer of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Suppressor of

Statement

Reference

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a suppressor | partially of visible | adult stage phenotype of Pink1^B9

(Xue et al., 2022)

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a suppressor | partially of abnormal jumping phenotype of Pink1^B9

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a suppressor of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a suppressor of visible | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^NP3084 is a suppressor | partially of partially lethal - majority die phenotype of Fer1HCH^GD4853, Scer\GAL4^NP3084

(Xiao et al., 2014)

NOT Suppressor of

Statement

Reference

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a non-suppressor of visible | adult stage phenotype of park^Δ21/park¹

(Xue et al., 2022)

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a non-suppressor of abnormal jumping phenotype of park^Δ21/park¹

(Xue et al., 2022)

Zip99C^UAS.cXa/mfrn^NIG.4963R, Scer\GAL4^Mhc.PU is a non-suppressor of abnormal jumping phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa has wing phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa has adult thorax phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Suppressor of

Statement

Reference

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a suppressor of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a suppressor of adult thorax phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a suppressor of adult somatic muscle cell of thorax phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a suppressor | partially of wing phenotype of Pink1^B9

(Xue et al., 2022)

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a suppressor | partially of adult thorax phenotype of Pink1^B9

(Xue et al., 2022)

NOT Suppressor of

Statement

Reference

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a non-suppressor of wing phenotype of park^Δ21/park¹

(Xue et al., 2022)

Zip99C^UAS.cXa/Scer\GAL4^Mhc.PU is a non-suppressor of adult thorax phenotype of park^Δ21/park¹

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a non-suppressor of indirect flight muscle cell phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The low eclosion rate and decreased total body iron content of Scer\GAL4^NP3084 Fer1HCH^GD4853 flies can be partially rescued by co-expression of Zip99C^Scer\UAS.cXa.

(Xiao et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Zip99C^Scer\UAS.cXa

Zip99C^UAS.cXa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Xiao

Secondary FlyBase IDs

References (3)

Report Sections

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