Imprecise excision of the P{XP} element in P{XP}mir-998d01508-3928 has resulted in an 87bp insertion within the mir-998 hairpin.
The mir-998exc222 was created by imprecise excision of P{XP}mir-998d01508-3928. 87 bases of the insertion remain at the site, which is within the mir-998 hairpin.
mir-998exc222 is an enhancer of increased cell death phenotype of Rbf120a
mir-998exc222 is a suppressor of visible phenotype of EgfrE1
mir-998exc222 is an enhancer of eye disc phenotype of Rbf120a
mir-998exc222 is a suppressor of eye phenotype of EgfrE1
mir-998exc222 is a suppressor of eye disc phenotype of EgfrE1
mir-998exc222 is a suppressor of ommatidium phenotype of EgfrE1
The generation of mir-998exc222 mutant eye disc clones enhances the amount of cell death seen in Rbf120a mutant eye discs.
mir-998exc222 strongly suppresses the reduction in ommatidial cluster number and rough eye phenotype seen in EgfrE1/+ mutant eye discs. When mir-998exc222 mutant clones are induced in EgfrE1 eye discs, the mutant phenotype is partially suppressed in cells immediately adjacent to the clones, suggesting non-cell autonomous effects.
The expression of E2f1 and mir-11 is unaffected.