FB2024_03 , released June 25, 2024
Allele: Hsap\MAPTUAS.2N4R
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General Information
Symbol
Hsap\MAPTUAS.2N4R
Species
H. sapiens
Name
FlyBase ID
FBal0295730
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
M{UAS-Tau.2N4R}
P{UAS-Tau.2N4R}
Key Links
Transgenic product class
wild_type
(Povellato et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Povellato et al., 2014)
Mutagen
in vitro construct
(Povellato et al., 2014)
Progenitor genotype
Carried in construct
M{UAS-Tau.2N4R}
P{UAS-Tau.2N4R}
Cytology
Description

UAS regulatory sequences drive expression of the 2N4R isoform of Hsap\MAPT.

(Povellato et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MAPT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEA
      (Povellato et al., 2014)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  tauopathy
      is exacerbated by sggS9A.UAS
      (Povellato et al., 2014)
      is exacerbated by Hsap\GSK3BUAS.cPa
      (Povellato et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Scer\GAL4GMR.PF>Hsap\MAPTScer\UAS.2N4R results in the disruption of the regular, crystalline array of ommatidia in the adult compound eye ranging from mild to severe. The severity of the disruption depends on the genomic insertion site of the transgene.

      (Povellato et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Hsap\MAPTUAS.2N4R, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by l(3)87Df[+]/l(3)87Dfunspecified

      (Povellato et al., 2014)
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Hsap\MAPTUAS.2N4R, Scer\GAL4GMR.PF has ommatidium phenotype, non-enhanceable by l(3)87Df[+]/l(3)87Dfunspecified

      (Povellato et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of sggS9A.Scer\UAS and Hsap\MAPTScer\UAS.2N4R under the control of Scer\GAL4GMR.PF results in increased eye disruption relative to the expression of each transgene alone. The ommatidia are more severely disrupted and patches of pigment loss and glazing are visible in the eyes of the mutants.

      (Povellato et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MAPTScer\UAS.2N4R
      Hsap\MAPTUAS.2N4R
      Name Synonyms
      Secondary FlyBase IDs
        References (1)