FB2024_03 , released June 25, 2024
Allele: Dmel\SH3PX1HMJ21552
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General Information
Symbol
Dmel\SH3PX1HMJ21552
Species
D. melanogaster
Name
FlyBase ID
FBal0294695
Feature type
allele
Associated gene
Dmel\SH3PX1
Associated Insertion(s)
Carried in Construct
P{TRiP.HMJ21552}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMJ21552}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMJ21552
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  colorectal cancer
      CEA
      (Zhang et al., 2019)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  colorectal cancer
      is ameliorated by EgfrJF01368
      (Zhang et al., 2019)
      is ameliorated by Ras85DJF02478
      (Zhang et al., 2019)
      is ameliorated by pntRNAi.UAS.cUa
      (Zhang et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adulthood-only expression of SH3PX1HMJ21552 under the control of Scer\GAL4esg.PU or under the combined control of Scer\GAL4esg.PU, Scer\GAL80Su(H).GBE leads to a progressive and severe increase in the number of mitotic cells (phospho-H3 staining) in the midgut and to intestinal dysplasia, as compared to controls; this outcome is not obtained when expression is driven by Scer\GAL4NP0001. (The temporal regulation of expression is dependent on Gal80[ts] and induced by temperature shift to 29[o]C for 7 days during adulthood)

      (Zhang et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by InRK1409A.UAS, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by domeHMS01293, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by bskGD10555, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by panΔN.UAS, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible by Dsor1KK102276, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible by Rab11JF02812, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by shi1.UAS, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible by EgfrUAS.cUa, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible by Ras85DJF02478, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible by pntRNAi.UAS.cUa, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by rhoJF03106, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible by spiJF03322, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      SH3PX1HMJ21552, Scer\GAL4esg.PU has increased occurrence of cell division | adult stage | progressive phenotype, suppressible | partially by Df(3L)Krn-27-7-B/Df(3L)Krn-27-7-B

      (Zhang et al., 2019)
      NOT suppressed by
      NOT Enhancer of
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SH3PX1HMJ21552
      Name Synonyms
      Secondary FlyBase IDs
        References (3)