FB2024_03 , released June 25, 2024
Allele: Dmel\mstUAS.ORF
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General Information
Symbol
Dmel\mstUAS.ORF
Species
D. melanogaster
Name
FlyBase ID
FBal0287239
Feature type
allele
Associated gene
Dmel\mst
Associated Insertion(s)
Carried in Construct
M{UAS-mst.ORF}
Key Links
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
in vitro construct
(Schertel et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-mst.ORF}
Cytology
Description

UASt regulatory sequences drive expression of a full-length mst open reading frame with its native stop codon.

(Schertel et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mst
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  myotonia congenita
      modeled by mstJF03280
      (Min et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing mstScer\UAS.ORF under the control of Scer\GAL4Mef2.PU exhibit a significant increase in gut contractions, an increased movement of food through the intestinal tract (and a significant increase in fecal deposition) a small but significant decrease in intestine diameter, and potentiated intestinal muscle fiber associated with thicker actin filaments, as compared to controls.

      (Min et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      mstUAS.ORF/Scer\GAL4Mef2.PU rescues mstJF03280

      (Min et al., 2017)
      Comments

      The co-expression of mstScer\UAS.ORF rescues the decreased lifespan, the decreased food intake, the decreased gut contractions, the dilated intestine, and the visceral muscle structure defects observed in adults expressing mstJF03280 under the control of Scer\GAL4Mef2.PU.

      (Min et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mstScer\UAS.ORF
      mstUAS.ORF
      Name Synonyms
      Secondary FlyBase IDs
        References (2)