FB2024_03 , released June 25, 2024
Allele: Dmel\AdamTS-AUAS.cIa
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General Information
Symbol
Dmel\AdamTS-AUAS.cIa
Species
D. melanogaster
Name
FlyBase ID
FBal0286142
Feature type
allele
Associated gene
Dmel\AdamTS-A
Associated Insertion(s)
Carried in Construct
P{UAS-AdamTS-A.I}
Also Known As
UAS-AdamTS-A
Key Links
Transgenic product class
wild_type
(Ismat et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ismat et al., 2013)
Mutagen
in vitro construct
(Ismat et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-AdamTS-A.I}
Cytology
Description

UAS regulatory sequences drive expression of AdamTS-A.

(Ismat et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
AdamTS-A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AdamTS-AUAS.RB under the control of Scer\GAL4elav.PU (combined with Scer\GAL80repo.PL) has no effect on larval brain morphology, however expression controlled by Scer\GAL4repo results in an elongated nerve cord and flattened brain lobes. Similar morphological defects are also observed upon Scer\GAL4repo-driven expression of AdamTS-AUAS.RB in the AdamTS-Arnwy1/AdamTS-Arnwy2 mutant larvae.

      (Skeath et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      AdamTS-AUAS.cIa/Scer\GAL4repo rescues AdamTS-Arnwy2/AdamTS-Arnwy1

      (Skeath et al., 2017)

      AdamTS-AUAS.cIa/Scer\GAL4elav.PU rescues AdamTS-Arnwy2/AdamTS-Arnwy1

      (Skeath et al., 2017)

      AdamTS-AUAS.cIa/Scer\GAL4VP16.nanos.UTR rescues AdamTS-AKO/Df(3R)88F5

      (Ismat et al., 2013)
      Partially rescues

      AdamTS-AUAS.cIa/Scer\GAL4tey-5053A partially rescues AdamTS-AKO/Df(3R)88F5

      (Ismat et al., 2013)

      AdamTS-AUAS.cIa/Scer\GAL4btl.PS partially rescues AdamTS-AKO/Df(3R)88F5

      (Ismat et al., 2013)
      Fails to rescue

      AdamTS-AUAS.cIa, Scer\GAL4elav.PU, Scer\GAL80repo.PL fails to rescue AdamTS-Arnwy2/AdamTS-Arnwy1

      (Skeath et al., 2017)
      Comments

      Expression of AdamTS-AUAS.cIa driven by Scer\GAL4elav.PU fails to rescue the neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures such as imaginal discs) characteristic for AdamTS-Arnwy1/AdamTS-Arnwy2 mutant larvae when combined with Scer\GAL80repo.PL, but the phenotype is rescued if the driver is used alone. Scer\GAL4repo-driven expression also rescues the invasion phenotype but replaces it with severe morphological anomalies: an elongated nerve cord and flattened brain lobes.

      (Skeath et al., 2017)

      Expression of AdamTS-AScer\UAS.cIa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 rescues the germ cell migration defects seen in AdamTS-AKO/Df(3R)88F5 embryos.

      Expression of AdamTS-AScer\UAS.cIa under the control of Scer\GAL4tey-5053A partially rescues the germ cell migration defects seen in AdamTS-AKO/Df(3R)88F5 embryos.

      Expression of AdamTS-AScer\UAS.cIa under the control of Scer\GAL4tey-5053A rescues the caudal visceral mesoderm migration defects seen in AdamTS-AKO/Df(3R)88F5 embryos.

      Expression of AdamTS-AScer\UAS.cIa under the control of either Scer\GAL4tey-5053A or Scer\GAL4btl.PS rescues the mis-migration of tracheal visceral branches seen in AdamTS-AKO/Df(3R)88F5 embryos.

      (Ismat et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AdamTS-AScer\UAS.cIa
      AdamTS-AUAS.cIa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)