FB2024_03 , released June 25, 2024
Allele: Dmel\hbΔAB.VP16.UAS
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General Information
Symbol
Dmel\hbΔAB.VP16.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0285808
Feature type
allele
Associated gene
Dmel\hb
Associated Insertion(s)
Carried in Construct
P{UAS-hb.ΔAB.VP16}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Tran et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hb.ΔAB.VP16}
Cytology
Description

UAS regulatory sequences drive expression of an hb polypeptide lacking the conserved domain AB fused with an N-terminal VP16 activation domain.

(Tran et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
hb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In wild-type, neuroblast NB7-1 generates five U motoneurons. Overexpression of hbΔAB.Scer\UAS.T:Hsim\VP16 in NB7-1 under the control of Scer\GAL4en-e16E produces an average of sixteen U neurons per hemisegment. Overexpression of hbΔAB.Scer\UAS.T:Hsim\VP16 in hb15/hbP1only mutant NB7-1 under the control of Scer\GAL4en-e16E produces an average of twelve U neurons per hemisegment.

      (Tran et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hbΔAB.Scer\UAS.T:Hsim\VP16
      hbΔAB.VP16.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)