FB2024_03 , released June 25, 2024
Allele: Dmel\lov47
Open Close
General Information
Symbol
Dmel\lov47
Species
D. melanogaster
Name
FlyBase ID
FBal0285145
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Imprecise excision of P{GawB}lov91Y resulting in deletion of 1.4 kb of sequence upstream of the original insertion (6.5 kb of P-element is retained), corresponding to intronic/flanking DNA not present in any final lov transcripts.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

Approximate boundaries of a 1.4 kb deletion resulting from the imprecise excison of P{GawB}lov91Y. 6.5 kb of the P element remain.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutants are viable with normal external adult morphology.

Homozygous are hemizygous females are highly fertile in terms of eggs laid and egg hatch rate. However, the resulting larvae show delayed development and poor growth. Fewer individuals survive to adulthood and surviving adults are often reduced in size. lov47 larvae are also smaller than controls. From hatching onwards, lov47 larvae are sluggish, showing less than half the locomotor activity of controls. These larvae also show bouts of spontaneous backwards movements in the absence of obvious triggers. Feeding activity is also depressed. lov47 larvae show normal food sensing/preference.

lov47 adults show essentially wild type responses to light, attractive and repellent tastes, repellent odors and water.

lov47 homozygous and hemizygous adults that complete climb assays have slower climb rates. In addition, significant numbers of these flies fail to complete climb tests.

lov47 hemizygous adults show poor viability, typically dying within 5 days of eclosion.

lov47 homozygous and hemizygous males exhibit significantly lower courtship levels compared to controls. In addition, lov47 males show significant 'non-directed' courtship (i.e. while not pursuing the female); lov47 hemizygous males tend to be immobile in the presence of females and display 'passive' courtship only when females are very close. In the absence of females, both lov47 homozygous and hemizygous males are at least as active as controls.

lov38/lov47 male courtship is decreased and show non-directed elements (while not pursuing the female).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)