Nucleotide substitution: G?A.
Amino acid replacement: W365term.
G17139956A
G?A
W365term | mei-218-PB; W365term | mei-218-PC; W365term | mei-218-PD; W365term | mei-218-PE
W365term
G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Homozygous females show 43.8% X chromosome nondisjunction and 28.2% 4th chromosome nondisjunction. Multiple chromosome masses are seen at metaphase I in 65% of homozygous oocytes.