FB2024_03 , released June 25, 2024
Allele: Dmel\rheaR367A.Ubi-p63E.EGFP
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General Information
Symbol
Dmel\rheaR367A.Ubi-p63E.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0283582
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
P{Ubi-talin.GFP.R367A}
Key Links
Transgenic product class
missense_variant
(Ellis et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ellis et al., 2011)
Mutagen
in vitro construct
(Ellis et al., 2011)
Progenitor genotype
Carried in construct
P{Ubi-talin.GFP.R367A}
Cytology
Description

Ubi-p63E promoter sequences drive expression of full-length rhea (sequence extends from 457bp upstream of the ATG codon to 100bp downstream of the stop codon) containing the amino acid replacement R367A. The protein is tagged with EGFP.

(Ellis et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
rhea
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      rheaR367A.Ubi-p63E.EGFP rescues Df(3L)79a

      (Ellis et al., 2011)
      Partially rescues

      rheaR367A.Ubi-p63E.EGFP partially rescues Df(3L)79a

      (Ellis et al., 2011)
      Comments

      The germband retraction and dorsal closure defects seen in embryos lacking maternal and zygotic rhea function (homozygous Df(3L)79a embryos derived from homozygous Df(3L)79a female germline clones) are rescued by expression of rheaR367A.Ubi-p63E.T:Avic\GFP-EGFP, but myotendinous junction defects are still seen in many late stage rescued embryos.

      (Ellis et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rheaR367A.Ubi-p63E.EGFP
      rheaR367A.Ubi-p63E.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)