UAS regulatory sequences drive expression of wild-type Hsap\HSPA1A coding sequences.
Hsap\HSPA1AUAS.cWa, Scer\GAL4repo is a suppressor of increased cell death | progressive phenotype of Hsap\GFAPUAS.cWa, Scer\GAL4repo
Hsap\HSPA1AUAS.cWa, Scer\GAL4repo is a suppressor of paralytic phenotype of Hsap\GFAPUAS.cWa, Scer\GAL4repo
Hsap\HSPA1AUAS.cWa, Scer\GAL4repo is a suppressor of lamina phenotype of Hsap\GFAPUAS.cWa, Scer\GAL4repo
Hsap\HSPA1AUAS.cWa, Scer\GAL4repo is a suppressor of adult brain phenotype of Hsap\GFAPUAS.cWa, Scer\GAL4repo
Hsap\HSPA1AUAS.cWa, Scer\GAL4repo is a suppressor of neuron | cell non-autonomous phenotype of Hsap\GFAPUAS.cWa, Scer\GAL4repo
Overexpression of Hsap\HSPA1AScer\UAS.cWa in flies expressing Hsap\GFAPScer\UAS.cWa under the control of Scer\GAL4repo results in a significant reduction in cell death. In addition, expression of Hsap\HSPA1AScer\UAS.cWa also decreases the number of seizures. Protection from cellular toxicity is accompanied by a significant reduction in the number of inclusion bodies and in activation of autophagy.
Overexpression of Hsap\HSPA1AScer\UAS.cWa in flies expressing Hsap\GFAPR79H.Scer\UAS under the control of Scer\GAL4repo results in a significant reduction in cell death. In addition, expression of Hsap\HSPA1AScer\UAS.cWa also decreases the number of seizures. Protection from cellular toxicity is accompanied by a significant reduction in the number of inclusion bodies and in activation of autophagy.