FB2024_03 , released June 25, 2024
Allele: Dmel\mysD807R.EYFP.Ubi-p63E
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General Information
Symbol
Dmel\mysD807R.EYFP.Ubi-p63E
Species
D. melanogaster
Name
FlyBase ID
FBal0282388
Feature type
allele
Associated gene
Dmel\mys
Associated Insertion(s)
Carried in Construct
P{Ubi-mys-YFP.D807R}
Key Links
Transgenic product class
missense_variant
(Pines et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Pines et al., 2011)
Mutagen
in vitro construct
(Pines et al., 2011)
Progenitor genotype
Carried in construct
P{Ubi-mys-YFP.D807R}
Cytology
Description

Ubi-p63E promoter sequences drive expression of mys coding sequences carrying a predicted activating mutation in the cytoplasmic domain (carries the amino acid replacement D807R, which disrupts inhibitory interactions with the α-integrin subunit).

(Pines et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
mys
Tagged with
EYFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      mysD807R.EYFP.Ubi-p63E rescues mys11

      (Pines et al., 2011)
      Fails to rescue

      mysD807R.EYFP.Ubi-p63E fails to rescue mys11

      (Pines et al., 2011)
      Comments

      Expression of mysD807R.T:Avic\GFP-EYFP.Ubi-p63E rescues both the germband retraction and dorsal closure phenotypes found in mys11 embryos.

      The mysD807R.T:Avic\GFP-EYFP.Ubi-p63E transgene fails to rescue the muscle detachment phenotype seen in mys11 embryos, with the myotendinous junctions appearing shorter and smaller overall, compared to wild-type.

      (Pines et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mysD807R.EYFP.Ubi-p63E
      mysD807R.T:Avic\GFP-EYFP.Ubi-p63E
      Name Synonyms
      Secondary FlyBase IDs
        References (2)