FB2024_03 , released June 25, 2024
Allele: Hsap\MFN2UAS.cDa
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General Information
Symbol
Hsap\MFN2UAS.cDa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Dorn
FlyBase ID
FBal0279443
Feature type
allele
Associated gene
Hsap\MFN2
Associated Insertion(s)
Carried in Construct
P{UAS-hMFN2.D}
Also Known As
UAS-hMFN2
Key Links
Transgenic product class
cDNA
(Dorn et al., 2011)
wild_type
(Dorn et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Dorn et al., 2011)
wild_type
(Dorn et al., 2011)
Mutagen
in vitro construct
(Dorn et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-hMFN2.D}
Cytology
Description

UASt regulatory sequences drive expression of a Hsap\MFN2 cDNA.

(Dorn et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MFN2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\MFN2Scer\UAS.cDa under the control of Scer\GAL4ey.3.5.Exel has no effect on eye area.

      Flies expressing Hsap\MFN2Scer\UAS.cDa under the control of Scer\GAL4tin.CΔ4 have normal climbing activity throughout a four-week experiment.

      Expression of Hsap\MFN2Scer\UAS.cDa under the control of Scer\GAL4tin.CΔ4 increases mitochondrial heterogeneity and induces mitochondrial fragmentation in adult cardiomyocytes.

      (Eschenbacher et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\MFN2Scer\UAS.cDa under the control of Scer\GAL4Feb36 restores the number of lipid droplets per ring gland to normal in MarfB wandering third instar larvae. However, the increase in bouton number seen at the neuromuscular junction in MarfB larvae is not rescued.

      (Sandoval et al., 2014)

      Co-expression of Hsap\MFN2Scer\UAS.cDa rescues the reduced eye area caused by expression of MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4ey.3.5.Exel.

      The progressive reduction in climbing ability and depressed heart tube fractional shortening of flies expressing MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4tin.CΔ4 is almost completely rescued by co-expression of Hsap\MFN2Scer\UAS.cDa.

      Mitochondrial fragmentation in the adult cardiomyocytes caused by expression of MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4tin.CΔ4 is almost completely suppressed by co-expression of Hsap\MFN2Scer\UAS.cDa.

      (Eschenbacher et al., 2012)

      Co-expression of Hsap\MFN2Scer\UAS.cDa completely rescues the heart tube defects (dilation and impaired shortening) seen in adults expressing MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4tin.CΔ4.

      (Dorn et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\MFN2Scer\UAS.cDa
      Hsap\MFN2UAS.cDa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Dorn
      Secondary FlyBase IDs
        References (5)