FlyBase Allele Report: Dmel\cnc[HMS02021]

General Information

Symbol

Dmel\cnc^HMS02021

Species

D. melanogaster

Name

FlyBase ID

FBal0279133

Feature type

allele

Associated gene

Dmel\cnc

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02021}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02021}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02021

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^Aβ42.lexAop

(Stapper and Jahn, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage, with Scer\GAL4^ppk.PU

(Chew et al., 2021)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.PU

(Kwon et al., 2018)

Phenotype Manifest In

dendrite | P-stage, with Scer\GAL4^ppk.PU

(Chew et al., 2021)

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^ppk.PU

(Chew et al., 2021)

larval multidendritic class IV neuron | P-stage, with Scer\GAL4^ppk.PU

(Chew et al., 2021)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^ppk.PU

(Kwon et al., 2018)

testis, with Scer\GAL4^bam.PU

(Chen et al., 2020)

Detailed Description

Statement

Reference

Expression of cnc^HMS02021 under the control of Scer\GAL4^bam.PU leads to accumulation of undifferentiated cells at the apex of the testis when compared to controls.

(Chen et al., 2020)

Expressing cnc^HMS02021 under the control of Scer\GAL4^ppk.PU results in a significantly reduced number of branch points in the dendrites of class IV dendritic arborizing neurons in third instar larvae compared to wild-type controls.

(Kwon et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^bam.PU, cnc^HMS02021 has testis phenotype, enhanceable by bam^Δ86

(Chen et al., 2020)