UAS regulatory sequences drive expression of a short inverted repeat.
Expression of Usp8HMS01898 under the control of Scer\GAL4Bx-MS1096 results in malformed adult wings.
Knockdown of Usp8HMS01898 driven in the class IV dendritic arborizing sensory neuron ddaC by Scer\GAL4ppk.1.9 leads to disruptions in pruning at 18hr after puparium formation, with dendrites still attached to the cell body (resulting from a lack of branch severing and clearance defects).
Flies expressing UbpyHMS01898 under the control of Scer\GAL4Dvir\Pdf.1.9 have a long locomotor activity period (1.3 hours longer than control flies).
Usp8HMS01898, Scer\GAL4GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\SNCAA53T.UAS, Scer\GAL4GMR.PU
Usp8HMS01898, Scer\GAL4GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\SNCAUAS.cFa, Scer\GAL4GMR.PU
Usp8HMS01898, Scer\GAL4Ddc.HL9 is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\SNCAA53T.UAS, Scer\GAL4Ddc.HL9
Usp8HMS01898, Scer\GAL4GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\HTT128Q.FL.UAS, Scer\GAL4GMR.PU
Usp8HMS01898, Scer\GAL4GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4GMR.PU
Usp8HMS01898, Scer\GAL4GMR.PU is a suppressor of eye | adult stage phenotype of Hsap\SNCAUAS.cFa, Scer\GAL4GMR.PU
Usp8HMS01898/Scer\GAL4GMR.PU is a suppressor | partially of dopaminergic PPM1 neuron | adult stage phenotype of Hsap\SNCAA53T.UAS, Scer\GAL4Ddc.HL9
Usp8HMS01898/Scer\GAL4GMR.PU is a suppressor | partially of dopaminergic PPM2 neuron | adult stage phenotype of Hsap\SNCAA53T.UAS, Scer\GAL4Ddc.HL9
Usp8HMS01898, Scer\GAL4GMR.PU is a suppressor of eye | adult stage phenotype of Hsap\SNCAA53T.UAS, Scer\GAL4GMR.PU
Usp8HMS01898, Scer\GAL4GMR.PU is a non-suppressor of eye | adult stage phenotype of Hsap\HTT128Q.FL.UAS, Scer\GAL4GMR.PU
Usp8HMS01898, Scer\GAL4GMR.PU is a non-suppressor of eye | adult stage phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4GMR.PU
The rough eye phenotype characteristic for adult flies expressing Hsap\SNCAScer\UAS.cFa under the control of Scer\GAL4GMR.PU is restored by co-expression of Usp8HMS01898.
The rough eye phenotype, the age-progressive decrease in climbing abilities as well as the loss of neurons in the PPM1/2 cluster observed in adult flies expressing Hsap\SNCAA53T.Scer\UAS under the control of Scer\GAL4Ddc.HL9 is rescued by co-expression of Usp8HMS01898 RNAi.
The rough eye phenotype characteristic for adult flies expressing either Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 or Hsap\HTT128Q.FL.Scer\UAS under the control of Scer\GAL4GMR.PU is not suppressed by expression of Usp8HMS01898.