FlyBase Allele Report: Dmel\Vps35[HMS01858]

General Information

Symbol

Dmel\Vps35^HMS01858

Species

D. melanogaster

Name

FlyBase ID

FBal0278975

Feature type

allele

Associated gene

Dmel\Vps35

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01858}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01858}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01858

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.2N4R.cSa

(Asadzadeh et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ddc.PU

(Linhart et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Vps35^HMS01858 driven by Scer\GAL4^Ddc.PU causes significant locomotor deficits (reduced climbing ability) in 5 or 10 (but not 20, when all flies including controls show age-dependent locomotor deficits) day old flies, compared to controls.

(Linhart et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Ddc.PU, Vps35^HMS01858 has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by Hsap\LRRK2^I2020T.UAS, Scer\GAL4^Ddc.PU

(Linhart et al., 2014)

NOT Enhancer of

Statement

Reference

Vps35^HMS01858, Scer\GAL4^Ddc.PU is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\LRRK2^I2020T.UAS, Scer\GAL4^Ddc.PU

(Linhart et al., 2014)

Other

Statement

Reference

ND-42^ninaE.GD6220, Scer\GAL4^54C, Vps35^HMS01858 has abnormal neurophysiology | adult stage | progressive phenotype

(Moulton et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

Vps35^HMS01858, Scer\GAL4^ninaE.PU is a suppressor of lipid droplet | adult stage phenotype of ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

Vps35^HMS01858, Scer\GAL4^ninaE.PU is a suppressor of pigment cell | adult stage phenotype of ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

Vps35^HMS01858, Scer\GAL4^54C is a suppressor of lipid droplet | adult stage phenotype of ND-42^ninaE.GD6220, Scer\GAL4^54C

(Moulton et al., 2021)

Vps35^HMS01858, Scer\GAL4^54C is a suppressor of pigment cell | adult stage phenotype of ND-42^ninaE.GD6220, Scer\GAL4^54C

(Moulton et al., 2021)

NOT Suppressor of

Statement

Reference

Vps35^HMS01858/Scer\GAL4^Mef2.PR is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Vps35^HMS01858/Scer\GAL4^Mef2.PR is a non-suppressor of flight muscle cell | adult stage phenotype of Pink1^B9

(Ham et al., 2021)

Other

Statement

Reference

ND-42^ninaE.GD6220, Scer\GAL4^54C, Vps35^HMS01858 has retina | adult stage phenotype

(Moulton et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\LRRK2^{I2020T.Scer\UAS} does not significantly enhance locomotor deficits in flies with expression of Vps35^HMS01858 driven by Scer\GAL4^Ddc.PU.

(Linhart et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38944

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01858}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Vps35^HMS01858

vps35^RNAi

(Shi et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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