FB2024_03 , released June 25, 2024
Allele: Hsap\ARFGAP1Δ64.UAS.Tag:HA
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General Information
Symbol
Hsap\ARFGAP1Δ64.UAS.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0278388
Feature type
allele
Associated gene
Hsap\ARFGAP1
Associated Insertion(s)
Carried in Construct
P{UAS-HA-Δ64.hArfGAP1}
Key Links
Transgenic product class
inframe_deletion
(Xiong et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Xiong et al., 2012)
Mutagen
in vitro construct
(Xiong et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-HA-Δ64.hArfGAP1}
Cytology
Description

UASt regulatory sequences drive expression of a mutated Hsap\ARFGAP1 coding sequence (with the first 1-64 amino acid residues removed) tagged at the N-terminal with Tag:HA.

(Xiong et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\ARFGAP1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\LRRK2G2019S.UAS.Tag:FLAG
      (Xiong et al., 2012)
      modeled by Hsap\LRRK2UAS.Tag:FLAG
      (Xiong et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\ARFGAP1Δ64.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ple.PF mildly reduces climbing ability.

      (Xiong et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\ARFGAP1Δ64.Scer\UAS.T:Ivir\HA1 with Hsap\LRRK2Scer\UAS.T:Zzzz\FLAG in dopaminergic neurons, under the control of Scer\GAL4ple.PF, rescues dopaminergic neuronal loss in the PPM1/2 but does not significantly rescue in the other dopaminergic clusters.

      Co-expression of Hsap\ARFGAP1Δ64.Scer\UAS.T:Ivir\HA1 with Hsap\LRRK2G2019S.Scer\UAS.T:Zzzz\FLAG in dopaminergic neurons, under the control of Scer\GAL4ple.PF, rescues dopaminergic neuronal loss in the PPM1/2 but does not significantly rescue in the other dopaminergic clusters.

      Co-expression of Hsap\ARFGAP1Δ64.Scer\UAS.T:Ivir\HA1 in dopaminergic neurons, under the control of Scer\GAL4ple.PF, rescues the climbing defect seen in Hsap\LRRK2Scer\UAS.T:Zzzz\FLAG- or Hsap\LRRK2G2019S.Scer\UAS.T:Zzzz\FLAG-expressing flies.

      (Xiong et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\ARFGAP1Δ64.Scer\UAS.T:Ivir\HA1
      Hsap\ARFGAP1Δ64.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)