Homozygous clones in the eye induced using the ey-FLP/FRT system result in overgrowth of the eye. Most of the overgrown tissue is Pka-C1[+], suggesting that the clone acts non-autonomously. Homozygous clones are recovered in the adult eye, but they are small, indicating that they have a growth disadvantage compared to Pka-C1[+] cells.