FB2024_03 , released June 25, 2024
Allele: Dmel\cosP50
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General Information
Symbol
Dmel\cosP50
Species
D. melanogaster
Name
FlyBase ID
FBal0278221
Feature type
allele
Associated gene
Dmel\cos
Associated Insertion(s)
Carried in Construct
Also Known As
cos2P50
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q580term.

    (Christiansen et al., 2013)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:7,385,128..7,385,128 [-]
    Nucleotide change:

    C7385128T

    Amino acid change:

    Q580term | cos-PA; Q580term | cos-PB

    Reported amino acid change:

    Q580term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Christiansen et al., 2013)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous clones in the eye induced using the ey-FLP/FRT system result in overgrowth of the eye. Most of the overgrown tissue is cos[+], suggesting that the clone acts non-autonomously. The homozygous clones are often present in the mutant eye, but they are small, indicating that they have a growth disadvantage compared to cos[+] cells. The ommatidia are often roughened and expanded along the anterior margin, even when this region is composed of cos[+] tissue.

        (Christiansen et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        cosP50 is a suppressor of eye phenotype of hidGMR.PG

        (Christiansen et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Eyes mosaic for cosP50 (generated using the ey-FLP/FRT system) moderately suppress the WGMR.PG eye phenotype. This suppression is cell non-autonomous.

        (Christiansen et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Cos2P50
        (Moore et al., 2022)
        cos2P50
        (Christiansen et al., 2013, Christiansen et al., 2012)
        cosP50
        Name Synonyms
        Secondary FlyBase IDs
          References (3)