FB2024_03 , released June 25, 2024
Allele: Hsap\MAPTUAS.S262A
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General Information
Symbol
Hsap\MAPTUAS.S262A
Species
H. sapiens
Name
FlyBase ID
FBal0277882
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\MAPT.S262A}
Also Known As
S262A tau
Key Links
Transgenic product class
missense_variant
(Iijima-Ando et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Iijima-Ando et al., 2010)
Mutagen
in vitro construct
(Iijima-Ando et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Hsap\MAPT.S262A}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Hsap\MAPT in which the serine at amino acid 262 has been replaced by alanine.

(Iijima-Ando et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MAPT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\MAPTScer\UAS.S262A under the control of Scer\GAL4GMR.PF causes age-dependent and progressive neurodegeneration in the lamina; degeneration in the lamina is undetectable or very mild in flies at 3-day old, but is prominent at 10 days old.

      (Iijima-Ando et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Hsap\MAPTUAS.S262A, Scer\GAL4GMR.PF has abnormal neuroanatomy | adult stage | conditional phenotype, non-enhanceable by miltGD8116, Scer\GAL4GMR.PF

      (Iijima-Ando et al., 2012)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Hsap\MAPTUAS.S262A, Scer\GAL4GMR.PF has lamina phenotype, non-enhanceable by miltGD8116, Scer\GAL4GMR.PF

      (Iijima-Ando et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of miltGD8116 does not enhance neurodegeneration in the lamina of 3 day old flies expressing Hsap\MAPTScer\UAS.S262A under the control of Scer\GAL4GMR.PF.

      (Iijima-Ando et al., 2012)

      Co-expression of Hsap\MAPTScer\UAS.S262A and lokScer\UAS.cPa under the control of Scer\GAL4GMR.PF has no effect on external eye size.

      (Iijima-Ando et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MAPTScer\UAS.S262A
      Hsap\MAPTUAS.S262A
      Name Synonyms
      Secondary FlyBase IDs
        References (4)