FB2024_03 , released June 25, 2024
Allele: Dmel\vnGAL4
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General Information
Symbol
Dmel\vnGAL4
Species
D. melanogaster
Name
FlyBase ID
FBal0277264
Feature type
allele
Associated gene
Dmel\vn
Associated Insertion(s)
P{GawB}vnGAL4
Carried in Construct
Also Known As
vn-Gal4
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Austin et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}vnGAL4
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        vnL6/vnGAL4 mutants die as white pupae with tiny white wing discs.

        (Austin et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of rhoScer\UAS.cUa under the control of Scer\GAL4vn.GAL4 partially suppresses the lethality seen in vnL6/vnGAL4 mutant flies. Approximately 50% of flies reach adulthood and have grossly normal wings, although the region between veins L3 and L4 is fused and some extra vein material is observed. The wing disc is of normal size and pattern.

        Expression of spis.Scer\UAS under the control of Scer\GAL4vn.GAL4 rescues the lethality of vnL6/vnGAL4 mutants to the pharate adult stage. The wings have fused L3 and L4 veins and extra vein material. The wing disc phenotype is partially rescues and no leg defects are observed. The extent of the rescue depends on the level of expression, but viable flies are never seen. Very high levels of expression are toxic, with animals dying as larvae.

        Expression of Krns.Scer\UAS.cUa under the control of Scer\GAL4vn.GAL4 rescues the lethality of vnL6/vnGAL4 mutants to the pharate adult stage. The wings have fused L3 and L4 veins and extra vein material. The wing disc phenotype is partially rescues and no leg defects are observed. The extent of the rescue depends on the level of expression, but viable flies are never seen. Very high levels of expression are toxic, with animals dying as embryos.

        Expression of grkΔTC.Scer\UAS under the control of Scer\GAL4vn.GAL4 rescues the lethality of vnL6/vnGAL4 mutants to the pharate adult stage. The wings have fused L3 and L4 veins and extra vein material. The wing disc phenotype is partially rescues and no leg defects are observed. The extent of the rescue depends on the level of expression, but viable flies are never seen. Very high levels of expression are toxic, with animals dying as pupae.

        Expression of spi::vnEGF.Scer\UAS under the control of Scer\GAL4vn.GAL4 rescues the lethality of vnL6/vnGAL4 mutants to the pharate adult stage.

        (Austin et al., 2014)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        vnL6/vnGAL4 is rescued by vnΔIg.UAS/Scer\GAL4vn-GAL4

        (Austin et al., 2014)
        Comments

        Expression of vnScer\UAS.cSa under the control of Scer\GAL4vn.GAL4 partially rescues the lethality seen in vnL6/vnGAL4 mutant flies. In optimal conditions approximately 30% of flies reach adulthood and have grossly normal patterning of the wing. Some extra vein material is observed. The wing disc phenotype is partially rescues and no leg defects are observed. The extent of the rescue depends on the expression level.

        Expression of vnΔIg.Scer\UAS under the control of Scer\GAL4vn.GAL4 rescues the lethality seen in vnL6/vnGAL4 mutant flies. The wings of these flies are abnormal and have deletion of wing margin bristles and notched margins, a phenotype that is also seen when this transgene is expressed in a wild type fly.

        (Austin et al., 2014)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        vnGAL4
        Name Synonyms
        Secondary FlyBase IDs
          References (2)