FB2024_03 , released June 25, 2024
Allele: Dmel\hoipGS7164
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General Information
Symbol
Dmel\hoipGS7164
Species
D. melanogaster
Name
FlyBase ID
FBal0276784
Feature type
allele
Associated gene
Dmel\hoip
Associated Insertion(s)
P{GSV2}GS7164
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Murata et al., 2008)
Progenitor genotype
Associated Insertion(s)
P{GSV2}GS7164
Cytology
Description

P{GSV2}GS7164 is inserted 413bp upstream of the hoip transcription start site.

(Murata et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{GSV2}
Regulatory region(s)
UASt
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Kennedy's disease
      modeled by Hsap\ARQ52AF-1.UAS
      (Murata et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hoipGS7164 in the developing eye under the control of Scer\GAL4GMR.PF has no effect on eye development.

      (Murata et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The presence of hoipGS7164 significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Hsap\ARQ52.Scer\UAS under the control of Scer\GAL4GMR.PF in the presence of 10[-5]M dehydrotestosterone. The numbers of rhabdomeres decreases significantly compared to single mutant controls.

      The presence of hoipGS7164 significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Hsap\ARQ52AF-1.Scer\UAS under the control of Scer\GAL4GMR.PF. The numbers of rhabdomeres decreases significantly compared to single mutant controls.

      The presence of hoipGS7164 significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF.

      (Murata et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hoipGS7164
      Name Synonyms
      Secondary FlyBase IDs
        References (1)