FB2024_03 , released June 25, 2024
Allele: Dmel\Mmp2NIG.1794-1R
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General Information
Symbol
Dmel\Mmp2NIG.1794-1R
Species
D. melanogaster
Name
FlyBase ID
FBal0272750
Feature type
allele
Associated gene
Dmel\Mmp2
Associated Insertion(s)
Carried in Construct
P{NIG.1794-1R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.1794-1R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-1794-1R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mmp2NIG.1794-1R under the control of Scer\GAL4Mef2.PU in embryos leads to heart development defects, including delayed collective cell migration of cardioblasts, with significantly decreased migration velocity; frequent gaps and clumps of cardioblasts are observed; cardioblasts exhibit significant reduction in the number of filopodia and lamellipodia; and the lumen fails to form correctly, as compared to wild type.

      (Raza et al., 2017)

      Expression of Mmp2NIG.1794-1R under the control of Scer\GAL4bab1-Pgal4-2 (using the temperature sensitive Scer\GAL80ts.αTub84B allele to limit expression to the adult stage) results in an increase in the proliferation of follicle precursor cells in region 2b of the germarium and an increase in the average number of cells in the interfollicle stalks compared to wild type.

      Expression of Mmp2NIG.1794-1R under the simultaneous control of both Scer\GAL4bab1-Agal4-5 and Scer\GAL4ptc-559.1 (using the temperature sensitive Scer\GAL80ts.αTub84B allele to limit expression to the adult stage) results in an increase in the average number of cells in the interfollicle stalks compared to wild type.

      (Wang and Page-McCaw, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmp2NIG.1794-1R
      Name Synonyms
      Secondary FlyBase IDs
        References (6)