FB2024_03 , released June 25, 2024
Allele: Dmel\snaSquish
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General Information
Symbol
Dmel\snaSquish
Species
D. melanogaster
Name
FlyBase ID
FBal0268954
Feature type
allele
Associated gene
Dmel\sna
Associated Insertion(s)
Carried in Construct
PBac{sna.Squish}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Dunipace et al., 2011)
Progenitor genotype
sna+t24.8
(Dunipace et al., 2011)
Carried in construct
PBac{sna.Squish}
Cytology
Description

Deletion of the intervening sequence present between the proximal and distal sna cis-regulatory modules.

(Dunipace et al., 2011)
Allele components
Component
Use(s)
Encoded product / tool
sna
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sna1/sna18;snaSquish mutant embryos exhibit normal gastrulation.

      In sna1/sna18;snaSquish mutant embryos the gland primordia degenerate and disappear.

      (Sánchez-Higueras et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of a Df(3L)H99 background (blocking apoptosis), results in the survival of the corpora allata and prothoracic glands in sna1/sna18;snaSquish mutant embryos, but they do not undergo epithelial-mesenchymal transition. As a result, the gland primordia maintain epithelial polarity, do not migrate, and form small pouches that remain attached to the epidermis.

      (Sánchez-Higueras et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      snaSquish fails to rescue sna18/sna1

      (Dunipace et al., 2011)
      Comments

      snaSquish rescues the gastrulation defects of sna1/sna18 embryos, but the animals are not rescued to adult viability.

      (Dunipace et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      snaSquish
      (Sánchez-Higueras et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)