FlyBase Allele Report: Dmel\Egfr[UAS.cUa]

General Information

Symbol

Dmel\Egfr^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0268507

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

P{UAS-Egfr.U}

Also Known As

UAS-EGFR, UAS-EGFR^wt

Key Links

Transgenic product class

wild_type

(Kim et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kim et al., 2012)

Mutagen

in vitro construct

(Kim et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Egfr.U}

Cytology

Description

UAS regulatory sequences drive expression of Egfr.

(Kim et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Egfr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

(Zhang et al., 2019)

visible, with Scer\GAL4^sca-537.4

(Kim et al., 2012)

visible, with Scer\GAL4^Ser.PGF

(Kim et al., 2012)

Phenotype Manifest In

adult midgut epithelium, with Scer\GAL4^esg.PU

(Zhang et al., 2019)

macrochaeta | ectopic, with Scer\GAL4^sca-537.4

(Kim et al., 2012)

metathoracic tergum, with Scer\GAL4^sca-537.4

(Kim et al., 2012)

wing, with Scer\GAL4^en-e16E

(Hahn et al., 2013)

wing vein, with Scer\GAL4^en-e16E

(Hahn et al., 2013)

wing vein | ectopic, with Scer\GAL4^Ser.PGF

(Kim et al., 2012)

Detailed Description

Statement

Reference

Adulthood-only expression of Egfr^UAS.cUa under the combined control of Scer\GAL4^esg.PU and Gal80[ts], induced by temperature shift to 29[o]C for 1-6 days during adulthood, leads to a mild increase in the number of mitotic cells (phospho-H3 staining) per adult midgut, as compared to controls.

(Zhang et al., 2019)

Overexpression of the wild-type Egfr^Scer\UAS.cUa construct in the posterior wing compartment, under the control of Scer\GAL4^en-e16E results in excess wing vein tissue is formed between L4 and L5.

(Hahn et al., 2013)

Overexpression of Egfr^Scer\UAS.cUa under the control of Scer\GAL4^Ser.PGF results in extra wing veins around the dorso-ventral boundary.

Overexpression of Egfr^Scer\UAS.cUa via Scer\GAL4^sca-537.4 results in extra bristles on the notum

(Kim et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has visible phenotype, enhanceable by pum⁰¹⁶⁸⁸/pum[+]

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has visible phenotype, enhanceable by pum^Msc/pum[+]

(Kim et al., 2012)

Enhancer of

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^elav.PU is an enhancer of abnormal memory | adult stage | progressive phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Wang et al., 2012)

NOT Enhancer of

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^Ser.PGF is a non-enhancer of visible phenotype of Scer\GAL4^Ser.PGF, pum^UAS.cKa

(Kim et al., 2012)

Suppressor of

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

NOT Suppressor of

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^Ser.PGF is a non-suppressor of visible phenotype of Scer\GAL4^Ser.PGF, pum^UAS.cKa

(Kim et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has metathoracic tergum phenotype, enhanceable by pum⁰¹⁶⁸⁸/pum[+]

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has macrochaeta | ectopic phenotype, enhanceable by pum⁰¹⁶⁸⁸/pum[+]

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has metathoracic tergum phenotype, enhanceable by pum^Msc/pum[+]

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has macrochaeta | ectopic phenotype, enhanceable by pum^Msc/pum[+]

(Kim et al., 2012)

Suppressed by

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^Ser.PGF has wing vein | ectopic phenotype, suppressible by pum^UAS.cKa, Scer\GAL4^Ser.PGF

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has metathoracic tergum phenotype, suppressible by pum^UAS.cKa, Scer\GAL4^sca-537.4

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has macrochaeta | ectopic phenotype, suppressible by pum^UAS.cKa, Scer\GAL4^sca-537.4

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has metathoracic tergum phenotype, suppressible by Scer\GAL4^sca-C253/pum^{HD.UAS.Tag:V5}

(Kim et al., 2012)

Egfr^UAS.cUa, Scer\GAL4^sca-537.4 has macrochaeta | ectopic phenotype, suppressible by Scer\GAL4^sca-C253/pum^{HD.UAS.Tag:V5}

(Kim et al., 2012)

Suppressor of

Statement

Reference

Egfr^UAS.cUa, Scer\GAL4^esg.PU is a suppressor of adult midgut epithelium | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Co-overexpression of pum^Scer\UAS.cKa with Egfr^Scer\UAS.cUa under the control of Scer\GAL4^Ser.PGF suppressed the development of ectopic wing veins resulting from the overexpression of Egfr^Scer\UAS.cUa alone generating wings that are indistinguishable from those overexpressing pum^Scer\UAS.cKa alone.

Heterozygous pum⁰¹⁶⁸⁸ greatly enhances the ectopic macrochaeta phenotype induced by Egfr^Scer\UAS.cUa overexpression in the notum under the control of Scer\GAL4^sca-537.4.

Heterozygous pum^Msc greatly enhances the ectopic macrochaeta phenotype induced by Egfr^Scer\UAS.cUa overexpression in the notum under the control of Scer\GAL4^sca-537.4.

Co-overexpression of pum^Scer\UAS.cKa and Egfr^Scer\UAS.cUa in the notum under the control of Scer\GAL4^sca-537.4 suppresses the Egfr^Scer\UAS.cUa-induced ectopic macrochaeta phenotype.

Concomitant expression of pum^{HD.Scer\UAS.T:SV5\V5} with Egfr^Scer\UAS.cUa is able to suppress the Egfr^Scer\UAS.cUa-induced ectopic bristle formation in the notum.

(Kim et al., 2012)

Xenogenetic Interactions

Statement

Reference

The age-progressive memory induced by expression of Hsap\APP^{Aβ1-42.Scer\UAS.cIa} under the control of Scer\GAL4^elav.PU is enhanced by co-expression of Egfr^Scer\UAS.cUa : the memory defect are detectable even in young 5-day-old flies that perform normally in the aversive olfactory memory assay when expressing Hsap\APP^{Aβ1-42.Scer\UAS.cIa} alone.

(Wang et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Egfr^Scer\UAS.cUa

Egfr^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (7)

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