FB2024_03 , released June 25, 2024
Allele: Dmel\CCKLR-17D1UAS.cCa
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General Information
Symbol
Dmel\CCKLR-17D1UAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Chen
FlyBase ID
FBal0267710
Feature type
allele
Associated gene
Dmel\CCKLR-17D1
Associated Insertion(s)
Carried in Construct
P{UAS-CCKLR-17D1.C}
Key Links
Transgenic product class
cDNA
(Chen and Ganetzky, 2012)
wild_type
(Chen and Ganetzky, 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Chen and Ganetzky, 2012)
wild_type
(Chen and Ganetzky, 2012)
Mutagen
in vitro construct
(Chen and Ganetzky, 2012)
Progenitor genotype
Carried in construct
P{UAS-CCKLR-17D1.C}
Cytology
Description

UAS regulatory sequences drive expression of a full length CCKLR-17D1 cDNA.

(Chen and Ganetzky, 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CCKLR-17D1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Presynaptic expression of CCKLR-17D1Scer\UAS.cCa under the control of Scer\GAL4elav-C155 substantially rescues the neuromuscular junction (NMJ) phenotype of Df(1)Exel9051/Y both for bouton number and NMJ morphology.

      Post-synaptic expression of CCKLR-17D1Scer\UAS.cCa under the control of Scer\GAL4how-24B fails to rescue the NMJ phenotype of Df(1)Exel9051/Y.

      Expression of CCKLR-17D1Scer\UAS.cCa in all muscles and motor neurons under the control of Scer\GAL4B185 substantially rescues the NMJ phenotype of Df(1)Exel9051/Y.

      Expression of CCKLR-17D1Scer\UAS.cCa preferentially in motor neurons under the control of Scer\GAL4Rapgap1-OK6 substantially rescues the NMJ phenotype of Df(1)Exel9051/Y.

      Overexpression of CCKLR-17D1Scer\UAS.cCa in muscle under the control of Scer\GAL4how-24B has no effect on NMJ morphology.

      Overexpression of two copies of CCKLR-17D1Scer\UAS.cCa in neurons under the control of Scer\GAL4elav.PLu results in a significant increase in synaptic bouton numbers at the larval NMJ.

      (Chen and Ganetzky, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The NMJ undergrowth phenotype of homozygous Dskf02468b is suppressed by Scer\GAL4elav-C155-driven overexpression of CCKLR-17D1Scer\UAS.cCa.

      (Chen and Ganetzky, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CCKLR-17D1Scer\UAS.cCa
      CCKLR-17D1UAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Chen
      Secondary FlyBase IDs
        References (2)