FB2024_03 , released June 25, 2024
Allele: Hsap\TARDBPUAS.Tag:MYC
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General Information
Symbol
Hsap\TARDBPUAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0261046
Feature type
allele
Associated gene
Hsap\TARDBP
Associated Insertion(s)
Carried in Construct
P{UAS-hTDP-43.Myc}
Also Known As
WT TDP-43
Key Links
Transgenic product class
wild_type
(Ritson et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ritson et al., 2010)
Mutagen
in vitro construct
(Ritson et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hTDP-43.Myc}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\TARDBP coding sequences tagged with Tag:MYC.

(Ritson et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\TARDBP
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Eye degeneration used to model disease.

      (Ritson et al., 2010)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Hsap\TARDBPUAS.Tag:MYC under the control of Scer\GAL4GMR.PF results in external eye degeneration.

      (Ramesh et al., 2020)

      At day one post eclosion flies expressing Hsap\TARDBPScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PU do not display any obvious eye defects but as they age the begin to show mild pigmentation loss.

      (Uechi et al., 2018)

      Expression of Hsap\TARDBPScer\UAS.cRa under the control of Scer\GAL4GMR.PF results in modest rough eye phenotype in adult flies.

      (Crippa et al., 2016)

      Ectopic expression of Hsap\TARDBPScer\UAS.cRa in the developing eye under the control of Scer\GAL4GMR.PF does not cause significant eye degeneration.

      (Lanson et al., 2011)

      Expression of Hsap\TARDBPScer\UAS.cRa in the developing eye under the control of Scer\GAL4GMR.PF results in a modest eye degeneration phenotype.

      (Ritson et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      NOT Enhancer of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      Hsap\TARDBPUAS.Tag:MYC, Scer\GAL4GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4GMR.PF, TER94UAS.cRa

      (Ritson et al., 2010)
      NOT Suppressor of
      Statement
      Reference

      Hsap\TARDBPUAS.Tag:MYC, Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, TER94UAS.cRa

      (Ritson et al., 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The moderate eye pigmentation loss observed in aged flies expressing Hsap\TARDBPScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PU is significantly enhanced by co-expression of CG5445NIG.5445R, in addition some flies (even young ones) display necrotic patches in the eye. On the other hand, co-expression of CG5445Scer\UAS.cUa slightly mitigates the progression of the pigmentation loss in Hsap\TARDBPScer\UAS.T:Hsap\MYC-expressing adults.

      (Uechi et al., 2018)

      The weak rough eye phenotype observed in adult flies expressing Hsap\TARDBPScer\UAS.cRa under the control of Scer\GAL4GMR.PF is not significantly modified by co-expression of either Hsp67BcScer\UAS.T:SV5\V5 or CG14207Scer\UAS.T:SV5\V5.

      (Crippa et al., 2016)

      Co-expression of Hsap\FUSScer\UAS.T:Ivir\HA1 and Hsap\TARDBPScer\UAS.cRa in the developing eye under the control of Scer\GAL4GMR.PF leads to moderate eye degeneration.

      Co-expression of Hsap\FUSR521H.Scer\UAS.T:Ivir\HA1 and Hsap\TARDBPScer\UAS.cRa in the developing eye under the control of Scer\GAL4GMR.PF leads to severe eye degeneration.

      (Lanson et al., 2011)

      Co-expression of TER94Scer\UAS.cRa and Hsap\TARDBPScer\UAS.cRa in the developing eye under the control of Scer\GAL4GMR.PF doesn't generate an eye phenotype, indicating there is no interaction between these transgenes.

      (Ritson et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\TARDBPScer\UAS.T:Hsap\MYC
      Hsap\TARDBPScer\UAS.cRa
      Hsap\TARDBPUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (11)