FlyBase Allele Report: Dmel\Hsp67Bc[UAS.Tag:V5]

General Information

Symbol

Dmel\Hsp67Bc^UAS.Tag:V5

Species

D. melanogaster

Name

FlyBase ID

FBal0248463

Feature type

allele

Associated gene

Dmel\Hsp67Bc

Associated Insertion(s)

Carried in Construct

P{UAS-Hsp67Bc.V5}

Also Known As

UAS-V5-HSP67Bc

Key Links

Transgenic product class

wild_type

(Carra et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Carra et al., 2010)

Mutagen

in vitro construct

(Carra et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Hsp67Bc.V5}

Cytology

Description

UAS drives expression of Hsp67Bc tagged with Tag:V5.

(Carra et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsp67Bc

Tagged with

Tag:V5

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Crippa et al., 2016)

ameliorates neurodegenerative disease

modeled by Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}

(Crippa et al., 2016)

modeled by Hsap\TARDBP^{TDP-35.UAS.Tag:HA}

(Crippa et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived, with Scer\GAL4^elav.PLu

(Vos et al., 2016)

long lived, with Scer\GAL4^ey.200.Exel

(Vos et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsp67Bc^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^GMR.PF has no significant effect on adult eye morphology.

(Crippa et al., 2016)

Overexpression of Hsp67Bc^{Scer\UAS.T:SV5\V5} driven by Scer\GAL4^elav.PLu or Scer\GAL4^ey.200.Exel leads to a small significant increase in lifespan compared to isogenic controls.

(Vos et al., 2016)

Overexpression of Hsp67Bc^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^Act5C.PI fails to protect against tachypacing-induced heart remodeling. Tachypacing also induces heart remodeling in wild-type flies.

(Zhang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a non-enhancer of visible | adult stage phenotype of Hsap\TARDBP^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Suppressor of

Statement

Reference

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor | partially of visible | adult stage phenotype of Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor | partially of abnormal eye color | adult stage phenotype of Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor of lethal - all die before end of pupal stage phenotype of Hsap\TARDBP^{TDP-35.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

NOT Suppressor of

Statement

Reference

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a non-suppressor of visible | adult stage phenotype of Hsap\TARDBP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Other

Statement

Reference

Hsap\TARDBP^{TDP-35.UAS.Tag:HA}, Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF has visible | adult stage phenotype

(Crippa et al., 2016)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\TARDBP^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Suppressor of

Statement

Reference

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a suppressor | partially of retina | adult stage phenotype of Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

NOT Suppressor of

Statement

Reference

Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\TARDBP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Crippa et al., 2016)

Other

Statement

Reference

Hsap\TARDBP^{TDP-35.UAS.Tag:HA}, Hsp67Bc^UAS.Tag:V5, Scer\GAL4^GMR.PF has eye phenotype

(Crippa et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The pupal lethality of flies expressing Hsap\TARDBP^{TDP-35.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is rescued by co-expression of Hsp67Bc^{Scer\UAS.T:SV5\V5}, but the adult flies display eye morphological defects - rough eye phenotype and partial (patchy) depigmentation.

The weak rough eye phenotype characteristic for adult flies expressing either Hsap\TARDBP^Scer\UAS.cRa or Hsap\TARDBP^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is not significantly modified by co-expression of Hsp67Bc^{Scer\UAS.T:SV5\V5}, whereas the eye degeneration phenotype (rough eye, depigmentation, partial loss of ommatidia) observed in flies expressing Hsap\TARDBP^{NLSmut.Scer\UAS} (also with Scer\GAL4^GMR.PF) is partially rescued.

(Crippa et al., 2016)

Co-expression of Hsp67Bc^{Scer\UAS.T:SV5\V5} significantly suppresses eye degeneration seen in flies with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PF.

(Vos et al., 2016)

Co-expression of Hsp67Bc^{Scer\UAS.T:SV5\V5} significantly decreases the eye degeneration seen in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

(Carra et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsp67Bc^{Scer\UAS.T:SV5\V5}

Hsp67Bc^UAS.Tag:V5

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close