FB2024_03 , released June 25, 2024
Allele: Dmel\Su(var)3-3NIG.17149R
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General Information
Symbol
Dmel\Su(var)3-3NIG.17149R
Species
D. melanogaster
Name
FlyBase ID
FBal0260633
Feature type
allele
Associated gene
Dmel\Su(var)3-3
Associated Insertion(s)
Carried in Construct
P{NIG.17149R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Eliazer et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Eliazer et al., 2011)
Mutagen
in vitro construct
(Eliazer et al., 2011)
Progenitor genotype
Carried in construct
P{NIG.17149R}
Cytology
Description

UASt regulatory sequences drive expression of an RNAi construct targeting Su(var)3-3.

(Eliazer et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-17149R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ovaries expressing Su(var)3-3NIG.17149R under the control of Scer\GAL4C587 show increased number of germline stem cell-like cells; escort cells show loss of extensions and increased apoptosis; there are fewer developing egg chambers.

      (Eliazer et al., 2014)

      Expression of Su(var)3-3NIG.17149R under the control of Scer\GAL4hh-Gal4 does not disrupt the normal morphology of the germarium.

      Expression of Su(var)3-3NIG.17149R under the control of Scer\GAL4C587 results in an increased number of single undifferentiated germline stem cell-like cells compared with wild-type.

      (Eliazer et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by raw134.47/raw[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by rawJF01382/Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by raw155.27/raw[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by Hnf4JF02539, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by Fkbp39HMS00339, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by Gfat1HMS02585, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by APC7GL01114, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by Scer\GAL4C587/barrHMS00049

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by CG11779GL01496, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible | partially by Scer\GAL4C587/kenHMS01219

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by en[+]/en4

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by en[+]/en7

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by Scer\GAL4C587/enHMS00595

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by enJF02316/Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by enspt/en[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by Scer\GAL4C587/hhJF01488

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by hh[+]/hhAC

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has increased cell number | oogenesis phenotype, suppressible by hh[+]/hh2

      (Eliazer et al., 2014)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number | oogenesis phenotype, suppressible by en[+]/en4

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number | oogenesis phenotype, suppressible by en[+]/en7

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number | oogenesis phenotype, suppressible by Scer\GAL4C587/enHMS00595

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number | oogenesis phenotype, suppressible by enJF02316/Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number | oogenesis phenotype, suppressible by enspt/en[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by en[+]/en4

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by en[+]/en7

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by enspt/en[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by Scer\GAL4C587/enHMS00595

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by enJF02316/Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by hh[+]/hh2

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by Scer\GAL4C587/hhJF01488

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible by hh[+]/hhAC

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by raw134.47/raw[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by raw155.27/raw[+]

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by rawJF01382/Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by Hnf4JF02539, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by Gfat1HMS02585, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by Fkbp39HMS00339, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by Scer\GAL4C587/barrHMS00049

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by APC7GL01114, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by CG11779GL01496, Scer\GAL4C587

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has egg chamber | decreased number phenotype, suppressible | partially by Scer\GAL4C587/kenHMS01219

      (Eliazer et al., 2014)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number phenotype, suppressible by Scer\GAL4C587/dppJF01090

      (Eliazer et al., 2011)

      Scer\GAL4C587, Su(var)3-3NIG.17149R has female germline stem cell | increased number phenotype, suppressible by Scer\GAL4C587/dppJF01091

      (Eliazer et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of dppJF01090 with Su(var)3-3NIG.17149R under the control of Scer\GAL4C587 strongly suppresses the supernumerary germline stem cell phenotype resulting from the expression of Su(var)3-3NIG.17149R.

      Co-expression of dppJF01091 with Su(var)3-3NIG.17149R under the control of Scer\GAL4C587 strongly suppresses the supernumerary germline stem cell phenotype resulting from the expression of Su(var)3-3NIG.17149R.

      (Eliazer et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Su(var)3-3NIG.17149R
      Name Synonyms
      Secondary FlyBase IDs
        References (4)