FlyBase Allele Report: Dmel\PEK[KK100348]

General Information

Symbol

Dmel\PEK^KK100348

Species

D. melanogaster

Name

FlyBase ID

FBal0258746

Feature type

allele

Associated gene

Dmel\PEK

Associated Insertion(s)

Carried in Construct

P{KK100348}

Also Known As

UAS-PERK^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100348}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100348

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Popovic et al., 2023)

ameliorates prion disease

modeled by Hsap\PRNP^V129.UAS.att

(Myers et al., 2022)

modeled by Hsap\PRNP^V129.UAS

(Fernandez-Funez et al., 2017)

ameliorates Galloway-Mowat syndrome 3

modeled by Tcs3^KK101323

(Krausel et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2015)

increased cell death | oogenesis, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

Phenotype Manifest In

adult gut | somatic clone, with Scer\GAL4^unspecified

(Wang et al., 2015)

egg chamber | decreased number, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

oocyte, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

stage S14 oocyte | increased number, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

yolk granule | decreased number, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

Detailed Description

Statement

Reference

Expression of PEK^KK100348 under the control of Scer\GAL4^109(2)80 does not significantly affect the total branch length of the dendritic arbor in class IV ddaC neurons in third instar larvae.

(Tsuyama et al., 2017)

Somatic MARCM clones in the adult gut expressing PEK^KK100348 under the Scer\GAL4^unspecified driver contain fewer cells compared to control clones.

(Wang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PEK^KK100348, Scer\GAL4^sns.PU is a suppressor of increased cell death phenotype of Scer\GAL4^sns.PU, Tcs3^KK101323

(Krausel et al., 2023)

PEK^KK100348, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

PEK^KK100348, Scer\GAL4^109(2)80 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^KK100348, Scer\GAL4^en.PU is a suppressor | partially of decreased cell size phenotype of Scer\GAL4^en.PU, sud1^GD742

(Katz et al., 2014)

PEK^KK100348, Scer\GAL4^en.PU is a suppressor | partially of visible phenotype of Scer\GAL4^en.PU, sud1^GD742

(Katz et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

PEK^KK100348, Scer\GAL4^sns.PU is a suppressor of nephrocyte diaphragm phenotype of Scer\GAL4^sns.PU, Tcs3^KK101323

(Krausel et al., 2023)

PEK^KK100348, Scer\GAL4^sns.PU is a suppressor of garland cell phenotype of Scer\GAL4^sns.PU, Tcs3^KK101323

(Krausel et al., 2023)

PEK^KK100348, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

PEK^KK100348, Scer\GAL4^109(2)80 is a suppressor | partially of abdominal dorsal multidendritic neuron ddaC | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^KK100348, Scer\GAL4^109(2)80 is a suppressor | partially of dendrite | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^KK100348, Scer\GAL4^en.PU is a suppressor | partially of 2nd posterior cell phenotype of Scer\GAL4^en.PU, sud1^GD742

(Katz et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prel^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^109(2)80 is strongly mitigated by co-expression of any of PEK^KK100348.

(Tsuyama et al., 2017)

Co-expression of PEK^KK100348 partially suppresses the reduced growth in the posterior compartment of the wing and the reduction in cell size caused by expression of sud1^GD742 under the control of Scer\GAL4^en.PU.

(Katz et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v110278

P{KK100348}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PEK^KK100348

(Myers et al., 2022)

PERK^RNAi

(Wang et al., 2015)

Perk[KK]

(Tsuyama et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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