FB2024_03 , released June 25, 2024
Allele: Dmel\Mlc2Δ2-46,S66A,S67A
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General Information
Symbol
Dmel\Mlc2Δ2-46,S66A,S67A
Species
D. melanogaster
Name
FlyBase ID
FBal0258599
Feature type
allele
Associated gene
Dmel\Mlc2
Associated Insertion(s)
Carried in Construct
P{Mlc2Δ2-46,S66A,S67A}
Also Known As
Dmlc2<up>Δ2-46; S66A,S67A</up>
Key Links
Transgenic product class
inframe_deletion
(Farman et al., 2009)
missense_variant
(Farman et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Farman et al., 2009)
missense_variant
(Farman et al., 2009)
Mutagen
in vitro construct
(Farman et al., 2009)
Progenitor genotype
Carried in construct
P{Mlc2Δ2-46,S66A,S67A}
Cytology
Description

Serines 66, 67 of Mlc2 are replaced by alanines in addition to lacking amino acids 2-46.

(Farman et al., 2009)
Allele components
Component
Use(s)
Encoded product / tool
Mlc2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mlc2E38 mutant flies expressing Mlc2Δ2-46,S66A,S67A are unable to fly or beat their wings.

      (Miller et al., 2011)

      Mlc2E38 mutants carrying Mlc2Δ2-46,S66A,S67A display sarcomeric structural abnormalities as revealed by X-ray diffraction and electron microscopy.

      (Farman et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dmlc2<up>Δ2-46; S66A,S67A</up>
      (Daneshparvar et al., 2020)
      Mlc2Δ2-46,S66A,S67A
      Name Synonyms
      Secondary FlyBase IDs
        References (3)