FlyBase Allele Report: Dmel\mtm[Δ77]

General Information

Symbol

Dmel\mtm^Δ77

Species

D. melanogaster

Name

FlyBase ID

FBal0258477

Feature type

allele

Associated gene

Dmel\mtm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Velichkova et al., 2010)

Progenitor genotype

P{EPgy2}CG9117^EY15305

(Velichkova et al., 2010)

Caused by aberration

Df(2L)mtm^Δ77

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes the CG9117 gene and part of mtm.

(Velichkova et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage

(Velichkova et al., 2010)

lethal - all die before end of larval stage (with mtm^z2-4747)

(Velichkova et al., 2010)

lethal - all die before end of larval stage (with mtm^Δ210)

(Velichkova et al., 2010)

some die during third instar larval stage

(Velichkova et al., 2010)

some die during third instar larval stage (with mtm^z2-4747)

(Velichkova et al., 2010)

some die during third instar larval stage (with mtm^Δ210)

(Velichkova et al., 2010)

Phenotype Manifest In

embryonic/larval hemocyte

(Velichkova et al., 2010)

embryonic/larval hemocyte (with mtm^z2-4747)

(Velichkova et al., 2010)

Detailed Description

Statement

Reference

Third instar mtm^Δ77/mtm^z2-4747 larvae show normal body wall muscle formation, attachments and growth.

(Ribeiro et al., 2011)

Primary hemocytes dissected from wild-type larvae undergo remodelling from a round to a spread cell shape, having F-actin rich radial protrusions. However, primary hemocytes derived from homozygous or mtm^Δ77/mtm^z2-4747 larvae lack these protrusions.

(Velichkova et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mtm^Δ77/mtm[+] is an enhancer of visible phenotype of if³

(Ribeiro et al., 2011)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

mtm^z2-4747/mtm^Δ77 has embryonic/larval hemocyte phenotype, non-suppressible by Pi3K59F^Δm22/Pi3K59F^Δm22

(Velichkova et al., 2010)

Enhancer of

Statement

Reference

mtm^Δ77/mtm[+] is an enhancer of wing phenotype of if³

(Ribeiro et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

mtm^Δ77/+ increases the penetrance of the wing blister phenotype seen in if³/Y flies from 33.7 +/- 2.5% to 65.4 +/- 4.7%.

(Ribeiro et al., 2011)

The lack of F-actin rich radial protrusions seen in primary hemocytes derived from mtm^Δ77/mtm^z2-4747 larvae is not rescued if the larvae also carry Pi3K59F^Δm22/Pi3K59F^Δm22.

(Velichkova et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mtm^z2-4747

(Velichkova et al., 2010)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mtm^Δ77

(Ribeiro et al., 2011, Velichkova et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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