FlyBase Allele Report: Dmel\tx[33-2]

General Information

Symbol

Dmel\tx^33-2

Species

D. melanogaster

Name

FlyBase ID

FBal0257988

Feature type

allele

Associated gene

Dmel\tx

Associated Insertion(s)

Mi{?ET1}tx^33-2

Carried in Construct

Also Known As

dei^33-2

Key Links

Allele class

Mutagen

transposable element activity

Nature of the Allele

Allele class

Mutagen

transposable element activity

(Egoz-Matia et al., 2011)

Progenitor genotype

Mi{ET1}tx^MB03174

(Egoz-Matia et al., 2011)

Associated Insertion(s)

Mi{?ET1}tx^33-2

Caused by aberration

Df(3R)tx^33-2

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 6.86kb deletion that removes the entire coding sequence of tx and two neighbouring genes (Hex-t1 and Hex-t2) as well as part of CG5447. A 2.7kb fragment of the original insertion remains.

(Egoz-Matia et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Nachman et al., 2015, Egoz-Matia et al., 2011)

visible | adult stage (with tx^ju-1)

(Varte et al., 2022)

Phenotype Manifest In

wing

(Nachman et al., 2015, Egoz-Matia et al., 2011)

wing (with tx^ju-1)

(Varte et al., 2022)

Detailed Description

Statement

Reference

Homozygotes have wing blisters and held out wings.

(Egoz-Matia et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

tx^33-2/tx[+] is an enhancer of visible | dominant phenotype of bs¹⁴

(Egoz-Matia et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

tx^33-2/tx[+] is an enhancer of wing vein | ectopic phenotype of bs¹⁴

(Egoz-Matia et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The extra wing vein phenotype of bs¹⁴/+ flies is more pronounced if they are also carrying tx^33-2/+.

(Egoz-Matia et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tx^ju-1

(Varte et al., 2022)

Partially rescued by

tx^33-2 is partially rescued by Scer\GAL4^GMR13A10/tx^UAS.cMa

(Nachman et al., 2015)

Not rescued by

tx^33-2 is not rescued by tx^UAS.cMa/Scer\GAL4^GMR12D06

(Nachman et al., 2015)

tx^33-2 is not rescued by tx^UAS.cMa/Scer\GAL4^GMR12H09

(Nachman et al., 2015)

Comments

Expression of tx^Scer\UAS.cMa under the control of Scer\GAL4^GMR13A10 significantly rescues the wing defects of tx^33-2 flies, while expression under the control of either Scer\GAL4^GMR12D06 or Scer\GAL4^GMR12H09 has no significant effect.

(Nachman et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dei^33-2

(Nachman et al., 2015, Egoz-Matia et al., 2011)

tx^33-2

(Varte et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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