The expression of mask^HMS01045 under the control of Scer\GAL4¹¹⁵¹ leads to decreased flight ability.

Expressing mask^HMS01045 under the control of Scer\GAL4^ey.PU induces a small eye phenotype.

Expression under the control of Scer\GAL4^en.PU induces substantial apoptosis in the wing disc.

Expression under the control of Scer\GAL4^repo.PU induces significant apoptosis in the larval brain.

Expression under the control of Scer\GAL4^moody.PU induces a compromised blood-brain barrier, as dye injected into the body cavity is able to diffuse into the adult retina or third instar larval brain. In agreement, larval subperineurial glial cells show disrupted/discontinuous septate junctions (Dlg immunostaining) and significant decreases in nuclear size and ploidy, as compared to controls. There is also a significant decrease in larval brain volume only at higher expression conditions (i.e. at 25[o]C but not at 18[o]C), as compared to controls.

Expressing mask^HMS01045 under the control of Scer\GAL4^how-24B results in the formation of significantly more autophagosomes and fewer autolysosomes (assessed by the red:green fluorescence ration of Atg8-GFP-mCherry puncta) in muscles throughout third instar larval stage. There is no change in pupal thoracic morphology and body size.

Flies expressing mask^HMS01045 under the control of Scer\GAL4^how-24B are pupal stage lethal.

Ectopic expression of mask^HMS01045 under the control of Scer\GAL4^how-24B results in defects in the mitochondrial connectivity in third instar larvae compared to controls.

mask^HMS01045, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.GFP, Scer\GAL4^GMR.PU

mask^HMS01045, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\FUS^{R521H.UAS.Tag:HA}, Scer\GAL4^GMR.PU

mask^HMS01045, Scer\GAL4^how-24B is an enhancer of decreased body size | P-stage | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

mask^HMS01045/Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of Atg1^UAS.cSa

mask^HMS01045, Scer\GAL4^how-24B is a non-enhancer of lethal - all die before end of P-stage | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor of abnormal size | larval stage phenotype of mir-285^KO.w-

Scer\GAL4^{Mhc.Switch.PO}/mask^HMS01045 is a suppressor | partially of abnormal flight phenotype of park^Δ21/park²⁵

mask^HMS01045, Scer\GAL4^how-24B is a non-suppressor of lethal - all die before end of P-stage | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

mask^HMS01045/Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Atg1^UAS.cSa

Scer\GAL4^how-24B, mask^HMS01045 has mitochondrion | third instar larval stage phenotype, non-suppressible by Drp1²/Drp1¹

Scer\GAL4^how-24B, mask^HMS01045 has embryonic/larval somatic muscle cell | third instar larval stage phenotype, non-suppressible by Drp1²/Drp1¹

mask^HMS01045, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\MAPT^UAS.GFP, Scer\GAL4^GMR.PU

mask^HMS01045, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\FUS^{R521H.UAS.Tag:HA}, Scer\GAL4^GMR.PU

Scer\GAL4^how-24B/mask^HMS01045 is an enhancer of mitochondrion | third instar larval stage phenotype of Scer\GAL4^how-24B, park^UAS.mCherry

Scer\GAL4^how-24B/mask^HMS01045 is an enhancer of embryonic/larval somatic muscle cell | third instar larval stage phenotype of Scer\GAL4^how-24B, park^UAS.mCherry

mask^HMS01045, Scer\GAL4^how-24B is a non-enhancer of pupal thorax | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

mask^HMS01045/Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Atg1^UAS.cSa

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor | partially of perineurium | larval stage phenotype of mir-285^KO.w-

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor | partially of perineurium | adult stage phenotype of mir-285^KO.w-

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor | partially of embryonic/larval CNS subperineurial glial cell | larval stage phenotype of mir-285^KO.w-

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor | partially of septate junction | larval stage phenotype of mir-285^KO.w-

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor of embryonic/larval brain | larval stage phenotype of mir-285^KO.w-

mask^HMS01045/Scer\GAL4^moody.PU is a suppressor of nucleus | larval stage phenotype of mir-285^KO.w-

Scer\GAL4^ple.PU/mask^HMS01045 is a suppressor | partially of mitochondrion | adult stage phenotype of park^Δ21/park²⁵

Scer\GAL4^ple.PU/mask^HMS01045 is a suppressor | partially of dopaminergic neuron | adult stage phenotype of park^Δ21/park²⁵

Scer\GAL4^ple.PU/mask^HMS01045 is a suppressor | partially of brain | adult stage phenotype of park^Δ21/park²⁵

Scer\GAL4^{Mhc.Switch.PO}/mask^HMS01045 is a suppressor | partially of indirect flight muscle cell phenotype of park^Δ21/park²⁵

Scer\GAL4^how-24B/mask^HMS01045 is a suppressor of mitochondrion | third instar larval stage phenotype of Pink1^B9

Scer\GAL4^how-24B/mask^HMS01045 is a suppressor of embryonic/larval somatic muscle cell | third instar larval stage phenotype of Pink1^B9

Scer\GAL4^how-24B/mask^HMS01045 is a suppressor of mitochondrion | third instar larval stage phenotype of park^Δ21/park²⁵

Scer\GAL4^how-24B/mask^HMS01045 is a suppressor of embryonic/larval somatic muscle cell | third instar larval stage phenotype of park^Δ21/park²⁵

Scer\GAL4^repo.PU/mask^HMS01045 is a non-suppressor of perineurium | larval stage phenotype of Scer\GAL4^repo.PU, mir-285^{UAS.DsRed(Unk)}

mask^HMS01045, Scer\GAL4^how-24B is a non-suppressor of pupal thorax | heat sensitive phenotype of Prosβ6^1.B.UAS, Scer\GAL4^how-24B

mask^HMS01045/Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Atg1^UAS.cSa