FB2024_03 , released June 25, 2024
Allele: Dmel\LpR2Df
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General Information
Symbol
Dmel\LpR2Df
Species
D. melanogaster
Name
FlyBase ID
FBal0256693
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Df(3R)lpr2
Key Links
Genomic Maps

Mutagen
Nature of the Allele
Associated Insertion(s)
Cytology
Description

Recombination between the two progenitor insertions has resulted in the deletion of the intervening sequence between them, producing a 29.7kb deletion which removes exons 1 to 8 of LpR2.

Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

Deletion of much of LpR2 resulting from FLP-catalyzed recombination using the FRT-containing transposons PBac{RB}LpR2e00374 and PBac{WH}LpR2f03030.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous females lay eggs but most of them fail to hatch, with the embryos dying at various stages of development and showing generalised apoptosis and pleiotropic phenotypes such as muscle detachment and nervous system malformations.

Homozygous stage 10 egg chambers show a marked decrease in lipid droplets compared to wild type.

Homozygous larval wing discs show a mild reduction in the level of intracellular lipid droplets compared to wild-type controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)