FB2024_03 , released June 25, 2024
Allele: Dmel\dppRNAi.UAS.cUa
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General Information
Symbol
Dmel\dppRNAi.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0248856
Feature type
allele
Associated gene
Dmel\dpp
Associated Insertion(s)
Carried in Construct
P{UAS-dpp.RNAi.U}
Also Known As
UAS-dppRNAi, UAS-dpp RNAi
Key Links
Transgenic product class
RNAi_reagent
(Liu et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Liu et al., 2010)
Mutagen
in vitro construct
(Liu et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-dpp.RNAi.U}
Cytology
Description

UAS regulatory sequences drive expression of a dpp RNAi construct.

(Liu et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dpp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  juvenile polyposis syndrome
      CEA
      (Guo et al., 2013)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Modest expression of dppdsRNA.Scer\UAS.cUa in the wing disc under the control of Scer\GAL4C-765 results in shortened wing veins L2 and L5 at low penetrance.

      (Chauhan et al., 2013)

      Expression of dppdsRNA.Scer\UAS.cUa under the control of Scer\GAL4GMR13B09 for eight days results in a dramatic increase in mitotic cell numbers as compared with wild-type.

      (Guo et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4C-765, dppRNAi.UAS.cUa has visible phenotype, enhanceable by LptRNAi.UAS, Scer\GAL4C-765

      (Chauhan et al., 2013)
      Suppressor of
      Statement
      Reference

      dppRNAi.UAS.cUa, Scer\GAL4C-765 is a suppressor | partially of visible phenotype of LptUAS.Tag:HA, Scer\GAL4C-765

      (Chauhan et al., 2013)
      Phenotype Manifest In
      Enhanced by
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous expression of dppdsRNA.Scer\UAS.cUa and LptdsRNA.Scer\UAS, both under the control of Scer\GAL4C-765, results in further shortening of the wing veins.

      Simultaneous expression of LptScer\UAS.T:Ivir\HA1 and dppdsRNA.Scer\UAS.cUa (both under the control of Scer\GAL4C-765) results in suppression of both the incomplete vein phenotypes observed upon dppdsRNA.Scer\UAS.cUa-expression as well as the ectopic vein phenotypes observed upon LptScer\UAS.T:Ivir\HA1 overexpression.

      (Chauhan et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dppRNAi.UAS.cUa
      dppdsRNA.Scer\UAS.cUa
      dppdsRNA.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (11)