Somatic clones of follicle cells homozygous mutant for Rab11^ΔFRT display defects in cell shape and adhesion in the egg chamber follicular epithelium.

Homozygous mushroom body gamma neuron clones show normal axon pruning.

Rab11^ΔFRT mutant eye disc clones exhibit no defects in ommatidial organisation.

After generation of Rab11^ΔFRT clones, a disproportionately small number of Rab11^ΔFRT germline stem cells (GSCs) are recovered compared with Rab11[ΔFRT] germline cysts. Rab11^ΔFRT GSCs have a half life of 4 days, which is approximately 4 fold less than wild type. Many of the germaria that lose a Rab11^ΔFRT GSC generate a wild type replacement for it so that they contain a full complement of wild type GSCs.

Rab11^ΔFRT germline stem cells have fewer adherens junctions, as judged by reduced shg and arm expression.

In contrast to wild type, the fusome of Rab11^ΔFRT germline stem cells is not anchored to the anterior cortex. Although spread out along the mitotic spindle during cell division, it is often splayed and generally much less organized than wild type.

All Rab11^ΔFRT germline cysts arrest development by stage 6 and are of two phenotypic classes. The rarer (~10%), more severely affected class arrest development in region 1 of the germarium, often contain less than 16 cells and have little or no fusome. The less affected class elaborate a normal fusome, but contain clumped ring canals and arrest development around stage 6. The nuclei of Rab11^ΔFRT germline cysts are also clumped together or otherwise poorly spaced. These cysts also exhibit defects in oocyte positioning - they are often in the centre rather than at the posterior end.