FB2024_03 , released June 25, 2024
Allele: Dmel\fzRNAi.UAS
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General Information
Symbol
Dmel\fzRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0246550
Feature type
allele
Associated gene
Dmel\fz
Associated Insertion(s)
Carried in Construct
P{UAS-fz.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Bastock and Strutt, 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Bastock and Strutt, 2007)
Mutagen
in vitro construct
(Bastock and Strutt, 2007)
Progenitor genotype
Carried in construct
P{UAS-fz.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a fragment of fz, encoding the first exon (682-1332 bp).

(Bastock and Strutt, 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of fzdsRNA.Scer\UAS under the control of Scer\GAL4slbo.2.6 results in significant delays in border cell migration at 29[o]C, but border cells usually reach the oocyte and no defects in border cell guidance are observed. A reduction in the number of large actin-protrusions from the border cell cluster compared to wild-type clusters is observed.

      Expression of fzdsRNA.Scer\UAS in the polar follicle cells under the control of Scer\GAL4slbo.2.6 results in delayed border cell migration.

      (Bastock and Strutt, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of fzdsRNA.Scer\UAS in border cells expressing Rho1N19.Scer\UAS under the control of Scer\GAL4slbo.2.6 does not alter the border cell phenotype observed when Rho1N19.Scer\UAS is expressed alone.

      Co-expression of fzdsRNA.Scer\UAS in border cells expressing Rho1V14.Scer\UAS under the control of Scer\GAL4slbo.2.6 ameliorates the rounded-border cell phenotype, and cells appear less round and produce actin-rich protrusions.

      (Bastock and Strutt, 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fzRNAi.UAS
      fzdsRNA.Scer\UAS
      fzdsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (5)