FB2024_03 , released June 25, 2024
Allele: Dmel\pros38
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General Information
Symbol
Dmel\pros38
Species
D. melanogaster
Name
FlyBase ID
FBal0246492
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
P{ET-mCD8-GFP}pros38
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{ET-mCD8-GFP}pros38
    Cytology
    Description

    Insertion of a P{ET-mCD8-GFP} construct into pros.

    (Tea and Luo, 2010.9.17)

    Insertion in the open reading frame at amino acid residue 188.

    (Tea et al., 2010)
    Allele components
    Component
    Use(s)
    Inserted element
    P{ET-mCD8-GFP}
    Encoded product / tool
    GFP
    Tagged with
    Tag:M(mCd8a)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous single-cell DL1 projection neuron clones mistarget their dendrites towards medial glomeruli (normally the dendrites of this projection neuron project to the dorsolateral glomerulus DL1). The mutant cells also show an axon overbranching phenotype in the lateral horn.

        (Tea et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT suppressed by
        Phenotype Manifest In
        NOT suppressed by
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of Rpd3Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GH146 in DL1 projection neuron clones which are mutant for pros38 does not rescue the dendrite mistargeting or axon overbranching defects seen in these mutant clones.

        (Tea et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        pros38 is rescued by prosL.UAS/Scer\GAL4GH146

        (Tea et al., 2010)
        Comments

        The dendrite mistargeting and axon overbranching phenotypes seen in pros38 DL1 projection neuron clones are rescued by expression in the clone of prosL.Scer\UAS under the control of Scer\GAL4GH146.

        (Tea et al., 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        pros38
        (Tea and Luo, 2010.9.17, Tea et al., 2010)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)