FlyBase Allele Report: Dmel\Mmp1[JF01336]

General Information

Symbol

Dmel\Mmp1^JF01336

Species

D. melanogaster

Name

FlyBase ID

FBal0245627

Feature type

allele

Associated gene

Dmel\Mmp1

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01336}

Also Known As

UAS-mmp1^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01336}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01336

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates intestinal cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Pranoto et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-fertile, with Scer\GAL4^Act.PU

(Deady et al., 2015)

Phenotype Manifest In

egg chamber, with Scer\GAL4^Act.PU

(Deady et al., 2015)

Detailed Description

Statement

Reference

Expression of Mmp1^JF01336 under the control of Scer\GAL4^GMR.PU does not lead to any photoreceptor degeneration and ommatidial disorganization in the adult eye.

(Yang et al., 2017)

Knockdown of Mmp1^JF01336 driven by Scer\GAL4^Act.PU during adulthood (using Scer\GAL80^ts.αTub84B) causes a slight but significant reduction in egg laying (but no increase in ovulation time), as well as a significant increase in mature eggs per female 6 hours post mating, compared to wild type.

(Deady et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Mmp1^JF01336/Scer\GAL4^R42A07.-FRT is an enhancer of visible | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, egr^{13xlexAop.cHa}

(Harris et al., 2020)

Mmp1^JF01336/Scer\GAL4^R42A07.-FRT is an enhancer of decreased size | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, egr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

Mmp1^JF01336, Scer\GAL4^esg.PU is a suppressor of hyperplasia | adult stage phenotype of Scer\GAL4^esg.PU, yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Pranoto et al., 2023)

NOT Suppressor of

Statement

Reference

Mmp1^JF01336, Scer\GAL4^Act.PU is a non-suppressor of neoplasia | somatic clone | third instar larval stage phenotype of BacA\p35^UAS.cHa, Scer\GAL4^Act.PU, Snr1^HMS00363

(Xie et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Mmp1^JF01336/Scer\GAL4^R42A07.-FRT is an enhancer of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, egr^{13xlexAop.cHa}

(Harris et al., 2020)

Suppressor of

Statement

Reference

Mmp1^JF01336, Scer\GAL4^esg.PU is a suppressor of adult posterior midgut phenotype of Scer\GAL4^esg.PU, yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Pranoto et al., 2023)

NOT Suppressor of

Statement

Reference

Mmp1^JF01336, Scer\GAL4^Act.PU is a non-suppressor of wing disc | somatic clone | third instar larval stage phenotype of BacA\p35^UAS.cHa, Scer\GAL4^Act.PU, Snr1^HMS00363

(Xie et al., 2017)

Mmp1^JF01336, Scer\GAL4^elav.PU, Hsap\CCN2^UAS.cYa is a non-suppressor of ommatidium | adult stage | progressive phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^GMR.PU

(Yang et al., 2017)

Mmp1^JF01336, Scer\GAL4^elav.PU, Hsap\CCN2^UAS.cYa is a non-suppressor of rhabdomere | adult stage | progressive phenotype of Hsap\APP^{Aβ42.UAS.cBa}, Scer\GAL4^GMR.PU

(Yang et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The aggressive tissue overgrowth observed in third instar larval wing discs carrying somatic (flip-out) clones simultaneously expressing Snr1^HMS00363 and BacA\p35^Scer\UAS.cHa driven by Scer\GAL4^Act.PU cannot be suppressed by co-expression Mmp1^JF01336.

(Xie et al., 2017)

The progressive photoreceptor degeneration in the adult eye observed upon Scer\GAL4^GMR.PU-driven expression of Hsap\APP^{Aβ42.Scer\UAS.cBa} can be significantly suppressed by co-expression of Hsap\CTGF^UAS.cYa but not by co-expression of Hsap\CTGF^UAS.cYa combined with Mmp1^JF01336.

(Yang et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31489

y¹ v¹; P{TRiP.JF01336}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mmp1^JF01336

Mmp1^RNAi

(Cho et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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