UAS regulatory sequences drive expression of an inverted repeat.
visible | adult stage, with Scer\GAL4A9
wing, with Scer\GAL4A9
Expressing MedJF02218 under the control of Scer\GAL4ppk.PU results in a significantly reduced number of branch points in the dendrites of class IV dendritic arborizing neurons in third instar larvae compared to wild-type controls.
Expression of MedJF02218 under the control of Scer\GAL4A9 results in the loss of distal parts of the L3, L4 and L5 wing veins and a decrease in wing size.
The adulthood-only expression of MedJF02218 under the control of Scer\GAL4esg.PU (in combination with Gal80[ts], for temporal regulation of expression) leads to a significant decrease in the relative and absolute size of secondary cell nuclei compared to neighboring main cells and wild-type controls; this expression does not affect the size of main cell nuclei compared to controls. The adulthood-only expression under the control of Scer\GAL4dsx.KI (and Gal80[ts]) leads to a significant decrease in the number of secretory vesicles within accessory gland secondary cells, associated with a significant decrease in the size of the largest multivesicular body/lysosome, as compared to controls; there is also a severe decrease in the secretion of (CD63-positive) exosomes into the accessory gland lumen.
The adulthood-only expression of MedJF02218 under the combined control of Scer\GAL4spi-NP0261 and Gal80[ts] also results in both virgin and mated males showing a significant increase in the number of dense core granule compartments within accessory gland secondary cells, as compared to matched controls.
MedJF02218, Scer\GAL4A9 has abnormal size | adult stage phenotype, suppressible | partially by anchorGD3613, Scer\GAL4A9
MedJF02218, Scer\GAL4A9 has visible | adult stage phenotype, suppressible | partially by anchorGD3613, Scer\GAL4A9
Scer\GAL4insc-Mz1407/MedJF02218 is a non-enhancer of increased cell number | larval stage phenotype of Vps35E42
Scer\GAL4insc-Mz1407/MedJF02218 is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of Vps35E42
MedJF02218, Scer\GAL4Delta-05151-G is a suppressor of abnormal cell number | adult stage phenotype of Scer\GAL4Delta-05151-G, ctripHMC02371
MedJF02218, Scer\GAL4A9 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4A9, anchorGD3613
MedJF02218, Scer\GAL4A9 is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4A9, anchorGD3613
Scer\GAL4insc-Mz1407/MedJF02218 is a non-suppressor of increased cell number | larval stage phenotype of Vps35E42
Scer\GAL4insc-Mz1407/MedJF02218 is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of Vps35E42
MadKK109050, MedJF02218, Scer\GAL4P2.4.Pdf has abnormal circadian rhythm phenotype
MedJF02218, Scer\GAL4A9 has wing phenotype, suppressible | partially by anchorGD3613, Scer\GAL4A9
Scer\GAL4insc-Mz1407/MedJF02218 is a non-enhancer of larval neuroblast | larval stage | increased number phenotype of Vps35E42
Scer\GAL4insc-Mz1407/MedJF02218 is a non-enhancer of embryonic/larval brain | larval stage phenotype of Vps35E42
MedJF02218, Scer\GAL4Delta-05151-G is a suppressor of intestinal stem cell of posterior adult midgut epithelium | decreased number phenotype of Scer\GAL4Delta-05151-G, ctripHMC02371
MedJF02218, Scer\GAL4Delta-05151-G is a suppressor of adult enteroendocrine cell | increased number phenotype of Scer\GAL4Delta-05151-G, ctripHMC02371
MedJF02218, Scer\GAL4Delta-05151-G is a suppressor of enteroblast | decreased number phenotype of Scer\GAL4Delta-05151-G, ctripHMC02371
MedJF02218, Scer\GAL4A9 is a suppressor | partially of wing vein phenotype of Scer\GAL4A9, anchorGD3613
Scer\GAL4insc-Mz1407/MedJF02218 is a non-suppressor of larval neuroblast | increased number | larval stage phenotype of Vps35E42
Scer\GAL4insc-Mz1407/MedJF02218 is a non-suppressor of embryonic/larval brain | larval stage phenotype of Vps35E42
The thickened wing vein phenotype of adults expressing anchorGD3613 under the control of Scer\GAL4A9 is partially suppressed by addition of MedJF02218. The decreased wing size phenotype of adults expressing MedJF02218 under the control of Scer\GAL4A9 is suppressed by addition of anchorGD3613.
Co-expression of MadKK109050 and MedJF02218 under the control of Scer\GAL4P2.4.Pdf reduces the strength of locomotor rhythmicity and induces strong arrhythmicity.