FlyBase Allele Report: Dmel\hpo[5.1]

General Information

Symbol

Dmel\hpo^5.1

Species

D. melanogaster

Name

FlyBase ID

FBal0244706

Feature type

allele

Associated gene

Dmel\hpo

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Genevet et al., 2009)

Progenitor genotype

P{EP}hpo^G3315

(Genevet et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 1983bp deletion that removes part of the 5'UTR, the coding start site, the whole first exon and part of the second exon of hpo.

(Genevet et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage | somatic clone

(Gaspar et al., 2015)

Phenotype Manifest In

eye | adult stage | somatic clone

(Gaspar et al., 2015)

interommatidial cell | pupal stage | somatic clone | increased number

(Gaspar et al., 2015)

interommatidial cell | somatic clone | increased number

(Dent et al., 2015)

Detailed Description

Statement

Reference

Homozygous clones generated using the eyFLP system result in eyes with an increased number of interommatidial cells compared to wild type.

(Dent et al., 2015)

hpo^5.1/hpo^5.1 eyes (created by the EGUF method in otherwise heterozygous animals) contain significantly increased number of inter-ommatidial cells in the pupal retina compared to wild-type and the adult eyes are overgrown and misshapen with folds.

(Gaspar et al., 2015)

Adults containing homozygous clones represent 34.3% of the population recovered after clones are induced using the eyFLP method (expected fraction of adults containing mutant clones is 50% if there is no effect of the mutant clones on viability).

(Genevet et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

hpo^5.1 has visible | adult stage phenotype, non-suppressible by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

Suppressor of

Statement

Reference

hpo^5.1/hpo[+] is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, kibra^EP747

(Genevet et al., 2010)

hpo^5.1 is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, kibra^UASp.cGa

(Genevet et al., 2010)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

hpo^5.1 has interommatidial cell | increased number | somatic clone phenotype, non-enhanceable by Git^ex21C

(Dent et al., 2015)

Suppressed by

Statement

Reference

hpo^5.1 has interommatidial cell | increased number | somatic clone | pupal stage phenotype, suppressible | partially by Zyx^Δ41/Zyx^Δ41

(Gaspar et al., 2015)

Suppressor of

Statement

Reference

hpo^5.1/hpo[+] is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, kibra^EP747

(Genevet et al., 2010)

hpo^5.1 is a suppressor of eye disc phenotype of Scer\GAL4^GMR.PF, kibra^UASp.cGa

(Genevet et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in the number of interommatidial cells which is seen in homozygous hpo^5.1 clones generated using the eyFLP system is not further enhanced if the clones are also homozygous for Git^ex21C.

(Dent et al., 2015)

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for hpo^5.1/hpo^5.1 eyes (created by the EGUF method in otherwise heterozygous animals) can be partially suppressed by combination with Zyx^Δ41/Zyx^Δ41 but the overgrowth and folded shape of the adult eyes cannot be rescued.

(Gaspar et al., 2015)

hpo^5.1 suppresses the ectopic apoptosis in the eye discs which is induced by expression of kibra^{Scer\UAS.P\T.cGa} under the control of Scer\GAL4^GMR.PF.

(Genevet et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hpo^5-1

(Boone et al., 2016)

hpo^5.1

(Poon et al., 2018, Dent et al., 2015, Gaspar et al., 2015, Vrabioiu and Struhl, 2015, Genevet et al., 2010, Genevet et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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