FB2024_03 , released June 25, 2024
Allele: Hsap\RDH12UAS.cWa
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General Information
Symbol
Hsap\RDH12UAS.cWa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Wang
FlyBase ID
FBal0244069
Feature type
allele
Associated gene
Hsap\RDH12
Associated Insertion(s)
Carried in Construct
P{UAS-RDH12.W}
Key Links
Transgenic product class
cDNA
(Wang et al., 2010)
wild_type
(Wang et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wang et al., 2010)
wild_type
(Wang et al., 2010)
Mutagen
in vitro construct
(Wang et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-RDH12.W}
Cytology
Description

UASt regulatory sequences drive expression of a Hsap\RDH12 cDNA.

(Wang et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\RDH12
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4rdhB.PW/Hsap\RDH12UAS.cWa is a suppressor of abnormal neurophysiology | recessive phenotype of Pdh1

      (Wang et al., 2010)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4rdhB.PW/Hsap\RDH12UAS.cWa is a suppressor of rhabdomere phenotype of Pdh1

      (Wang et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\RDH12Scer\UAS.cWa under the control of Scer\GAL4CG7077.PW in retinal pigment cells partially suppresses the Pdh1 phenotype as measured in electroretinogram recordings. Deactivation afterpotential is generated in flies expressing Hsap\RDH12Scer\UAS.cWa in retinal pigment cells even after 7 days under a 12 hour light/12 hour dark cycle, although they are reduced relative to wild-type. Expressing Hsap\RDH12Scer\UAS.cWa in retinal pigment cells also diminishes the severity of the retinal degeneration in Pdh1 flies.

      (Wang et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\RDH12Scer\UAS.cWa
      Hsap\RDH12UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Wang
      Secondary FlyBase IDs
        References (1)