FB2024_03 , released June 25, 2024
Allele: Dmel\spdo3R6
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General Information
Symbol
Dmel\spdo3R6
Species
D. melanogaster
Name
FlyBase ID
FBal0243887
Feature type
allele
Associated gene
Dmel\spdo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Hutterer and Knoblich, 2005)
Mutagen
ethyl methanesulfonate
(Hutterer and Knoblich, 2005)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Hutterer and Knoblich, 2005)

Amino acid replacement: Q91term.

(Hutterer and Knoblich, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:30,477,083..30,477,083 [+]
Nucleotide change:

C30477083T

Reported nucleotide change:

C?T

Amino acid change:

Q91term | spdo-PA

Reported amino acid change:

Q91term

(Hutterer and Knoblich, 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Centrosome asymmetry during cytokinesis in mutant pI (sensory organ precursor) cells in the notum is identical to that seen in wild-type pI cells.

      (Jauffred et al., 2013)

      spdo3R6 animals show loss of microchaetae on the head capsule and loss of eye interommatidial bristles.

      In spdo3R6 mutant external sensory organs, outer cells are transformed into inner cells. 22% of all head external sensory organs are comprised of four neurons, and 6% have two sheath cells and two neurons. Mutant sensory organ precursor cells frequently divide symmetrically into two pIIb cells.

      (Hutterer and Knoblich, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      spdo3R6
      (Jauffred et al., 2013, Hutterer and Knoblich, 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)