FB2024_03 , released June 25, 2024
Allele: Dmel\NctST2
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General Information
Symbol
Dmel\NctST2
Species
D. melanogaster
Name
FlyBase ID
FBal0243771
Feature type
allele
Associated gene
Dmel\Nct
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Zhang et al., 2005)
Mutagen
ethyl methanesulfonate
(Zhang et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: S333F.

(Zhang et al., 2005)

Nucleotide substitution: C?T.

(Zhang et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,852,885..24,852,885 [+]
Nucleotide change:

C24852885T

Reported nucleotide change:

C?T

Amino acid change:

S333F | nct-PA; S333F | nct-PC; S333F | nct-PD; S333F | nct-PE

Reported amino acid change:

S333F

(Zhang et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous nctST2 large mutant eye disc clones (generated in a Minute/+ background) display very few neurons, and an overall reduction in disc size is observed. On the contrary, small nctST2 clones (generated in a wild-type background) display supernumerary neurons, and extra R8 neurons are present. The nuclei of these extra cells are often observed in basal locations not normally occupied by photoreceptor neuron nuclei, and occasionally some nuclei drop into the optic stalk. These misplaced nuclei are always observed in the posterior region of clones, in the more mature neurons. Apicobasal polarity and epithelial integrity is very occasionally disrupted in these cells.

      (Zhang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      NctST1

      (Zhang et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NctST2
      nctST2
      (Zhang et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)