FB2024_03 , released June 25, 2024
Allele: Dmel\Mdr65MI00104
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General Information
Symbol
Dmel\Mdr65MI00104
Species
D. melanogaster
Name
FlyBase ID
FBal0242792
Feature type
allele
Associated gene
Dmel\Mdr65
Associated Insertion(s)
Mi{MIC}Mdr65MI00104
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}Mdr65MI00104
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Injection of 25mM valproate saline solution affords seizure resistance in Mdr65MI00104 mutants.

        (Howlett and Tanouye, 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Mdr65MI00104 is a suppressor | partially of paralytic | drug conditional phenotype of eas1

        (Howlett and Tanouye, 2013)

        Mdr65MI00104 is a suppressor of paralytic | drug conditional phenotype of parabss1

        (Howlett and Tanouye, 2013)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        A Mdr65MI00104 background does not affect the seizure phenotype found in parabss1 flies that have been injected with 15mM valproate saline solution. However, the seizure phenotype found in parabss1; Mdr65MI00104 flies that have been injected with 25mM valproate saline solution is considerably higher, and above the wild-type range, indicating some protection conferred by an interaction in the double mutant.

        A Mdr65MI00104 background partially suppresses the seizure phenotype in eas1 flies.

        (Howlett and Tanouye, 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Mdr65MI00104
        (Bellen, 2010.3.31)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)