FlyBase Allele Report: Dmel\ey[OK107-16]

General Information

Symbol

Dmel\ey^OK107-16

Species

D. melanogaster

Name

FlyBase ID

FBal0242604

Feature type

allele

Associated gene

Dmel\ey

Associated Insertion(s)

P{GawB}OK107

Carried in Construct

Also Known As

OK107-GAL4, OK107, GAL4-OK107, ey^OK107-gal4, OK107GAL4, OK107 Gal4, P{GawB}ey^OK107, ey-Gal4, 0K107-Gal4, OK107-G4

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Clements et al., 2009)

Progenitor genotype

P{GawB}OK107

(Clements et al., 2009)

Associated Insertion(s)

P{GawB}OK107

Cytology

Description

Amino acid replacement: P101L.

(Clements et al., 2009)

Nucleotide substitution: C390T.

(Clements et al., 2009)

The progenitor P{GawB}ey^OK107 insertion is still present on the chromosome, in addition to the lesion induced within the ey coding region (numbering system used to describe the lesion is as used by FBrf0074219).

(Clements et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

4:712,519..712,519 [+]

Nucleotide change:

C712519T

Reported nucleotide change:

C390T

Amino acid change:

P101L | ey-PA; P120L | ey-PC; P161L | ey-PD

Reported amino acid change:

P101L

(Clements et al., 2009)

transposable_element_insertion_site

4:698,501..698,501 [-]

(Clements et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Clements et al., 2009)

visible (with ey²)

(Clements et al., 2009)

visible (with ey^D1Da)

(Clements et al., 2009)

visible (with ey^EH)

(Clements et al., 2009)

visible (with ey^JD)

(Clements et al., 2009)

visible (with ey^OK107-4)

(Clements et al., 2009)

visible (with ey^OK107-6)

(Clements et al., 2009)

visible (with ey^OK107-10)

(Clements et al., 2009)

Phenotype Manifest In

adult central complex (with ey^D1Da)

(Clements et al., 2009)

adult central complex (with ey^EH)

(Clements et al., 2009)

adult central complex (with ey^JD)

(Clements et al., 2009)

adult central complex (with ey^OK107-4)

(Clements et al., 2009)

adult central complex (with ey^OK107-6)

(Clements et al., 2009)

adult central complex (with ey^OK107-10)

(Clements et al., 2009)

adult mushroom body

(Clements et al., 2009)

adult mushroom body (with ey^D1Da)

(Clements et al., 2009)

adult mushroom body (with ey^EH)

(Clements et al., 2009)

adult mushroom body (with ey^JD)

(Clements et al., 2009)

adult mushroom body (with ey^OK107-4)

(Clements et al., 2009)

adult mushroom body (with ey^OK107-6)

(Clements et al., 2009)

adult mushroom body (with ey^OK107-10)

(Clements et al., 2009)

eye

(Clements et al., 2009)

eye (with ey²)

(Clements et al., 2009)

eye (with ey^D1Da)

(Clements et al., 2009)

eye (with ey^EH)

(Clements et al., 2009)

eye (with ey^JD)

(Clements et al., 2009)

eye (with ey^OK107-4)

(Clements et al., 2009)

eye (with ey^OK107-6)

(Clements et al., 2009)

eye (with ey^OK107-10)

(Clements et al., 2009)

Detailed Description

Statement

Reference

Homozygotes show a reduction in the size of the eye (this phenotype is variable both between different animals and between the two eyes of the same animal). Severe disruption is seen in the mushroom bodies, with loss of lobes often being seen.

(Clements et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions