FlyBase Allele Report: Dmel\Drp1[JF02762]

General Information

Symbol

Dmel\Drp1^JF02762

Species

D. melanogaster

Name

FlyBase ID

FBal0242344

Feature type

allele

Associated gene

Dmel\Drp1

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02762}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02762}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02762

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

exacerbates hypoplastic left heart syndrome

modeled by Chchd3^HMC02376

(Birker et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval fat body | early third instar larval stage, with Scer\GAL4^Cg.PA

(Liu et al., 2020)

mitochondrion | adult stage, with Scer\GAL4^Mef2.PR

(Wang et al., 2016)

mitochondrion | early third instar larval stage, with Scer\GAL4^Cg.PA

(Liu et al., 2020)

Detailed Description

Statement

Reference

Expressing Drp1^JF02762 under the control of Scer\GAL4^Cg.PA results in enlarged mitochondria (showing as large blobs) in the early third instar larval fat body.

(Liu et al., 2020)

Expression of Drp1^JF02762 under the control of Scer\GAL4^Mef2.PR results in enlarged mitochondria in adult indirect flight muscles.

(Wang et al., 2016)

Flies expressing Drp1^JF02762 under the control of Scer\GAL4^GMR.PU do not exhibit any discernible eye phenotype, as compared to controls.

(Hwang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Drp1^JF02762, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Other

Statement

Reference

Drp1^JF02762, Hsap\UCP2^UAS.cFa, Scer\GAL4^GMR.PU has visible phenotype

(Hwang et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Drp1^JF02762, Scer\GAL4^Cg.PA has embryonic/larval fat body | early third instar larval stage phenotype, suppressible | partially by Chchd2^8-8

(Liu et al., 2020)

Drp1^JF02762, Scer\GAL4^Cg.PA has mitochondrion | early third instar larval stage phenotype, suppressible | partially by Chchd2^8-8

(Liu et al., 2020)

Drp1^JF02762, Scer\GAL4^Mef2.PR has mitochondrion | adult stage phenotype, suppressible | partially by clu^UAS.Tag:MYC, Scer\GAL4^Mef2.PR

(Wang et al., 2016)

Enhancer of

Statement

Reference

Drp1^JF02762, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Other

Statement

Reference

Chchd3^HMC02376, Drp1^JF02762, Scer\GAL4^HCH.Hand has adult heart phenotype

(Birker et al., 2023)

Chchd3^HMC02376, Drp1^JF02762, Scer\GAL4^HCH.Hand has filamentous actin | adult stage phenotype

(Birker et al., 2023)

Drp1^JF02762, Hsap\UCP2^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype

(Hwang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of clu^UAS.Tag:MYC alleviates the swollen mitochondria phenotype observed in adult indirect flight muscles of flies expressing Drp1^JF02762 under the control of Scer\GAL4^Mef2.PR.

(Wang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\UCP2^Scer\UAS.cFa and Drp1^JF02762 under the control of Scer\GAL4^GMR.PU results in a rough eye phenotype.

(Hwang et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27682

y¹ v¹; P{TRiP.JF02762}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Drp1^JF02762

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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